| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Research Abstract |
To examine the existence of"trans-generational memory" in innate immunity, we used Drosophila melanogaster as a model system and did generational infection experiments. Gene expression profiling analyses revealed that some innate immunity-related gene expression patterns in response to a bacteria infection is significantly different between test group that has been infected at previous generations and the control group not infected previously. The results suggest the possibility that organism which only has innate immunity can"memorize" environmental stress, and that the"memory" can be maintained across generations.
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