Role of stress-activated signaling pathway in mechanical stress-induced bone remodeling

• Project/Area Number: 21890014
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: MATSUI Hiroyuki Tohoku University, 加齢医学研究所, 教育研究支援者 (10547277)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 骨免疫学 / メカノバイオロジー / MAPキナーゼ / JNK・p38 / NF-κB / シグナル伝達 / 骨代謝

Research Abstract

Mechanical stress to bone is important for the maintenance of bone homeostasis. Osteoblast, which performs bone formation derived from mesenchymal cells, osteoclast which is responsible for bone resorption is hematopoietic stem cell origin like as other immune cells. Thus, osteoimmunological study is increasingly needed for the interpretation of osteoblast-osteoclast interaction. This study has unveiled that TAK1 MAPKKK was activated by mechanical stretch loading in osteoblast, and induced the expression of IL-6, an osteoclastogenic factor, via its downstream signaling pathway.

Research Products

• [Journal Article] TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts. (2011)
  • Author(s): Naoto Fukuno, Hiroyuki Matsui (Authors contributed equally)
  • Journal Title: Biochemical and Biophysical Research Communications Volume: in press
  • Peer Reviewed
• [Journal Article] Expression patterns of collagen types I and III in the capsule of a rat knee contracture model. (2010)
  • Author(s): Yoshihiro Hagiwara, Akira Ando, Yoshito Onda, Hiroyuki Matsui, Eiichi Chimoto, Hideaki Suda, Eiji Itoi
  • Journal Title: J.Orthop Res. 28(3) Pages: 315-21
  • Peer Reviewed
• [Journal Article] Expression patterns of collagen types I and III in the capsule of a rat knee contracture model. (2010)
  • Author(s): Yoshihiro Hagiwara
  • Journal Title: Journal of Orthopaedic Research Volume: 28(3) Pages: 315-321
  • Peer Reviewed
• [Journal Article] 骨芽細胞におけるメカニカルストレスセンサー分子 (2009)
  • Author(s): 松井裕之,福野直人,神田佳明,鈴木治,佐々木啓一,小林孝安,田村眞理
  • Journal Title: 第10回(社)計測自動制御学会システムインテグレーション部門講演会論文集 Pages: 1663-1664
• [Journal Article] Mechanical stress induces the activation of TAK1 and its downstream pathways in pre-osteoblastic cells. (2009)
  • Author(s): Naoto Fukuno, Hiroyuki Matsui, Yoshiaki Kanda, Osamu Suzuki, Kunihiro Matsumoto, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura
  • Journal Title: Proc.MHS Pages: 383-384
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): H.Matsui, et al.
  • Journal Title: Mechanical stress Modulates bone remodeling signals(Springer) Pages: 129-132
• [Journal Article] TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6
  • Author(s): Naoto Fukuno, Hiroyuki Matsui, Yoshiaki Kanda, Osamu Suzuki, Kunihiro Matsumoto, Keiichi Sasaki, Takayasu Kobayashi, Shinri Tamura.
  • Journal Title: expression in osteoblasts. Biochem Biophys Res Commun.(有) Pages: 2011-2011
• [Presentation] 骨芽細胞のJNKおよびp38は骨メカノバイオロジーにおいて破骨細胞とのサイトカインクロストークに寄与する (2010)
  • Author(s): 松井裕之,福野直人,神田佳明,鈴木治,武田弘資,一條秀憲,佐々木啓一,小林孝安,田村眞理
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(ポスター)(口頭)
• [Presentation] 骨芽細胞のJNKおよびp38は骨メカノバイオロジーにおいて破骨細胞とのサイトカインクロストークに寄与する (2010)
  • Author(s): 松井裕之
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場((口頭)(ポスター))
• [Presentation] 骨芽細胞におけるメカニカルストレスセンサー分子 (2009)
  • Author(s): 松井裕之
  • Organizer: SI2009第10回計測自動制御学会システムインテグレーション部門講演会
  • Place of Presentation: 芝浦工業大学
  • Year and Date: 2009-12-26
• [Presentation] TAK1 is activated by cyclic mechanical strain loading to pre-osteoblastic cells. (2009)
  • Author(s): 福野直人
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] Mechanical stress Induced the Activation of TAK1 and its Down stream Pathways in Pre-osteoblastic Cells. (2009)
  • Author(s): 福野直人
  • Organizer: 第20回マイクロ・ナノメカトロニクスとヒューマンサイエンスに関する2009年国際シンポジウム(MHS2009 & Micro-Nano Global COE)
  • Place of Presentation: 名古屋大学
  • Year and Date: 2009-11-10
• [Presentation] Mechanical stress modulates bone remodeling signals (2009)
  • Author(s): Hiroyuki Matsui, Naoto Fukuno, Kohsuke Takeda, Hidenori Ichijo, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura, Keiichi Sasaki
  • Organizer: TOHOKU-FORSYTH Symposium, at Forsyth Institute
  • Place of Presentation: Boston(招待講演)
• [Presentation] Mechanical stress modulates bone remodeling signals (2009)
  • Author(s): Hiroyuki Matsui, Naoto Fukuno, Kohsuke Takeda, Hidenori Ichijo, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura, Keiichi Sasaki
  • Organizer: US-Japan Symposium, at Convention Center Niigata
  • Place of Presentation: 招待講演
• [Book] Interface Oral Health Science(Mechanical stress modulates bone remodeling signals) (2009)
  • Author(s): Hiroyuki Matsui, Naoto Fukuno, Kohsuke Takeda, Hidenori Ichijo, Osamu Suzuki, Takayasu Kobayashi, Shinri Tamura, Keiichi Sasaki
  • Publisher: Springer