| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Research Abstract |
To elucidate whether Bim and CD226 are involved in megakaryopoiesis and platelet function, we characterized megakaryocytes and platelets in bim knockout (KO) mice and CD226 KO mice. We have demonstrated the dual role of Bim during megakaryopiesis, namely the control of apoptotsis and cell cycle progression. We have suggested that CD226 is involved in platelet production and platelet function.
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