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The influence of the anesthetics on cerebral nerve circuit construction in period of growth by visible of the GABAergic neurons

Research Project

Project/Area Number 21890032
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGunma University

Principal Investigator

KUBO Kazuhiro  Gunma University, 医学部, 助教 (80546531)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,911,000 (Direct Cost: ¥1,470,000、Indirect Cost: ¥441,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,001,000 (Direct Cost: ¥770,000、Indirect Cost: ¥231,000)
KeywordsGFP / GAD67 / 吸入麻酔薬
Research Abstract

I administered 1.5% sevoflurane for each 12 hours on 1st day, 3rd day and 5th day after birth. After maturity, I examined teachability to go through a hippocampus, a base nucleus, a cerebral cortex, the cerebellum by Morris water maze test. As a result, the teachability of the sevoflurane treated group, the teachability of the sense of position in particular did not have a difference in comparison with the non-anesthesia group either.
Next, I examined Elevated plus maze test. As a result, the tendency that an anxiety behavior increased was seen with the sevoflurane treated group.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65.2009

    • Author(s)
      Kubo K, Nishikawa K, Ishizeki J, Hardy-Yamada M, Yanagawa Y, Saito S.
    • Journal Title

      The Journal of pharmacology and experimental therapeutics 331(1)

      Pages: 162-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase.2009

    • Author(s)
      Kubo K, Nishikawa K, Hardy-Yamada M, Ishizeki J, Yanagawa Y, Saito S.
    • Journal Title

      The Journal of pharmacology and experimental therapeutics 329

      Pages: 592-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 652009

    • Author(s)
      Kubo K
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 331(1)

      Pages: 162-169

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase2009

    • Author(s)
      Kubo K
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 329(2)

      Pages: 592-599

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] セボフルラン麻酔からの覚醒への低用量レミフェンタニル持続併用の影響2010

    • Author(s)
      天田早香
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] セボフルラン麻酔からの覚醒への低容量レミフェンタニル持続併用の影響2010

    • Author(s)
      天田早香
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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