| Project/Area Number |
21890035
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Human genetics
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| Research Institution | Chiba University |
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Principal Investigator |
SATO Yasunori Chiba University, 医学部附属病院, 講師 (90536723)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | ゲノム / 薬剤反応性 / 統計科学 / 遺伝疫学 / ゲノム網羅的アプローチ / ファーマコゲノミクス / 一塩基多型(SNP) / 生物統計手法 / 母集団薬物動態解析 / 一塩基多型 / 薬物動態解析 / 統計学的アプローチ / 生存時間解析 |
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| Research Abstract |
The purpose of this research is to examine problems of study design and analyzing methods for genome-wide pharmacogenomics studies from statistical viewpoints, and then to present new proposals in order to contribute to the development of personalized. In this study, three specific issues were addressed regarding the genome-wide pharmacogenomics studies as follows ; i) Statistical analysis for the association between pharmacokinetics and SNP, ii) Statistical analysis for the association between clinical outcome and SNP, iii) Statistical analysis for PK and SNP-PD modeling. These findings of research were reported in academic journals and meetings.
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