| Project/Area Number |
21890036
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Chiba University |
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Principal Investigator |
SUZUKI Kotaro Chiba University, 大学院・医学研究院, 特任助教 (90554634)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | アレルギー / 肥満細胞 / 脱顆粒 / NF-kB / アレルギー性炎症 / type I IFN / STAT4 |
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| Research Abstract |
1) RelA, which is a main molecule of NF-kBs, is not involved in antigen-mediated degranulation from mast cells, but plays an important role in pro-inflammatory cytokine production leading to late phase allergic reaction. 2) STAT4 is essential for IFN-β-induced MCP-1 expression in mast cells. Because mast cells are distributed in almost all tissues, our results suggest that mast cells may be involved in the enhancement of the antiviral responses initiated by pDC by producing MCP-1 in response to type I IFNs-STAT4 signals.
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