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Analyses of regulatory mechanism of mast cell degranulation

Research Project

Project/Area Number 21890036
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionChiba University

Principal Investigator

SUZUKI Kotaro  Chiba University, 大学院・医学研究院, 特任助教 (90554634)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsアレルギー / 肥満細胞 / 脱顆粒 / NF-kB / アレルギー性炎症 / type I IFN / STAT4
Research Abstract

1) RelA, which is a main molecule of NF-kBs, is not involved in antigen-mediated degranulation from mast cells, but plays an important role in pro-inflammatory cytokine production leading to late phase allergic reaction. 2) STAT4 is essential for IFN-β-induced MCP-1 expression in mast cells. Because mast cells are distributed in almost all tissues, our results suggest that mast cells may be involved in the enhancement of the antiviral responses initiated by pDC by producing MCP-1 in response to type I IFNs-STAT4 signals.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009

All Presentation (5 results)

  • [Presentation] 肥満細胞のI型IFN応答におけるSTAT4の役割の解明2010

    • Author(s)
      鈴木浩太郎
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥満細胞のI型IFN応答におけるSTAT4の役割の解明2010

    • Author(s)
      鈴木浩太郎
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role of STAT4 in Mast Cells2010

    • Author(s)
      鈴木浩太郎
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Related Report
      2010 Final Research Report
  • [Presentation] The Role of STAT4 in Mast Cells2010

    • Author(s)
      鈴木浩太郎
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸(兵庫県)
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] マスト細胞におけるRelAの役割り2009

    • Author(s)
      鈴木浩太郎
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-12-05
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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