Roles of intraoral digestion on regulation of glucose metabolism

• Project/Area Number: 21890040
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Chiba University
• Principal Investigator: KASAMATSU Atsushi Chiba University, 医学部附属病院, 助教 (60375730)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 口腔内消化 / 糖代謝 / 生理学 / 糖代謝制御 / インスリン分泌 / インクレチン分泌

Research Abstract

Intraoral digestion triggers various biological responses via taste sensation and/or nutrient absorption at upper intestine. Nevertheless, the effect of sweet sensation on the regulation of glucose metabolism remains unknown. We measured GLP-1 secretion in response to test meal ingestion in Japanese male volunteers. Unexpectedly, GLP-1 secretion occurred synchronously with blood glucose rise and non-nutritive sweetener failed to trigger GLP-1 secretion. Therefore, the early GLP-1 secretion requires the direct stimulation with nutrients in the gut rather than the sweet sensation on the tongue.