Role of Asialoglycoprotein receptor in tumor microenvironment

• Project/Area Number: 21890044
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: HAYAKAWA Yoshihiro The University of Tokyo, 大学院・薬学系研究科, 准教授 (10541956)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000); Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000); Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
• Keywords: がん / 転移 / レクチン / 糖鎖 / シグナル伝達 / アシアロ糖蛋白質レセプター / がん転移 / MMP-9 / EGFR / ERK / 糖たんぱく質 / 免疫監視 / NK細胞

Research Abstract

The importance of the interaction between endogenous lectins and glycans on cancer cells has been explored. In this study, we demonstrated that the importance of hepatic asialoglycoprotein receptor (ASGPR), C-type lectin with the preference in the recognition of galactose or N-acetylgalactosamine residue of the counter receptor, in the formation of metastasis of cancer cells.

Research Products

• [Journal Article] The Interactions of Multiple Cytokines Control NK Cell Maturation. (2010)
  • Author(s): Brady J, Carotta S, Thong RP, Chan CJ, Hayakawa Y, Smyth MJ, Nutt SL
  • Journal Title: The Journal of Immunology 185 Pages: 6679-6688
  • Peer Reviewed
• [Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules. (2010)
  • Author(s): Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MW, Yoshizawa H, Yagita H, Gejyo F, Okumura K, Smyth MJ
  • Journal Title: The Journal of Immunology 184 Pages: 5439-5501
  • Peer Reviewed
• [Journal Article] Subset analysis of human and mouse mature NK cells. (2010)
  • Author(s): Hayakawa Y, Andrews DM, Smyth MJ
  • Journal Title: Methods Mol.Biol. 612 Pages: 27-38
  • Peer Reviewed
• [Journal Article] The Interactions of Multiple Cytokines Control NK Cell Maturation. (2010)
  • Author(s): Brady J, Carotta S, Thong RR, Chan CJ, Hayakawa Y, Smyth MJ, Nutt SL.
  • Journal Title: The Journai of Immunology Volume: 185 Pages: 6679-6688
  • Peer Reviewed
• [Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules. (2010)
  • Author(s): Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MW, Yoshizawa H, Yagita H, Gejyo F. Okumura K, Smyth MJ.
  • Journal Title: The Journal of Immunology Volume: 184 Pages: 5439-5501
  • Peer Reviewed
• [Journal Article] In vivo imaging of obesity-induced inflammation in adipose tissue. (2010)
  • Author(s): Fushiki H, Hayakawa Y, Gomori A, Seo T, Tewari S, Ozaki S, Yoshimoto R.
  • Journal Title: Biochem Biophys Res Commun. 391 Pages: 674-678
  • Peer Reviewed
• [Journal Article] Subset analysis of human and mouse mature NK cells. (2010)
  • Author(s): Hayakawa Y, Andrews DM, Smyth MJ.
  • Journal Title: Methods Mol Biol. 612 Pages: 27-38
  • Peer Reviewed
• [Journal Article] In vivo imaging of obesity-induced inflammation in adipose tissue. (2009)
  • Author(s): Fushiki H, Hayakawa Y, Gomori A, Seo T, Tewari S, Ozaki S, Yoshimoto R
  • Journal Title: Biochem Biophys Res Commun. 391 Pages: 674-678
  • Peer Reviewed
• [Journal Article] Quantification of mouse pulmonary cancer models by microcomputed tomography imaging. (2009)
  • Author(s): Fushiki H, Kanoh-Azuma T, Katoh M, Kawabata K, Jiang J, Tsuchiya N, Satow A, Tamai Y, Hayakawa Y
  • Journal Title: Cancer Sci. 100 Pages: 1544-1559
  • NAID: 10027193794
  • Peer Reviewed
• [Journal Article] Reduction of autofluorescence of in vivo fluorescence imaging by using purified diet. (2009)
  • Author(s): Fushiki H, Hayakawa Y
  • Journal Title: Nippon Yakurigaku Zasshi 134 Pages: 13-16
  • NAID: 10025741057
  • Peer Reviewed
• [Journal Article] Quantification of mouse pulmonary cancer models by microcomputed to mography imaging. (2009)
  • Author(s): Fushiki H, Kanoh-Azuma T, Katoh M, Kawabata K, Jiang J, Tsuchiya N, Satow A, Tamai Y, Hayakawa Y.
  • Journal Title: Cancer Sci. 100 Pages: 1544-1559
  • Peer Reviewed
• [Journal Article] Reduction of autofluorescence of in vivo fluorescence imaging by using purified diet. (2009)
  • Author(s): Fushiki H, Hayakawa Y.
  • Journal Title: Nippon Yakurigaku Zasshi. 134 Pages: 13-16
  • NAID: 10025741057
  • Peer Reviewed
• [Presentation] Tatsuro Irimura Evidences for cancer immune-escalation process and the role of inflammatory cytokines. (2011)
  • Author(s): 早川芳弘
  • Organizer: Keystone Symposia "Cancer Control by Tumor Suppressors and Immune Effectors"
  • Place of Presentation: anta Fe Community Convention Center (Santa Fe, USA)
  • Year and Date: 2011-02-14
• [Presentation] Evidences for cancer immune-escalation process and the role of inflammatory cytokines (2011)
  • Author(s): Yoshihiro Hayakawa, Tatsuro Irimura
  • Organizer: Keystone Symposia "Cancer Control by Tumor Suppressors and Immune Effectors"
  • Place of Presentation: Santa Fe Community Convention Center (Santa Fe, USA)
  • Year and Date: 2011-02-14
• [Presentation] Requirement of endogenous IFN-gamma for effective recruitment of effector NK cells into tumor microenvironment. (2010)
  • Author(s): 早川芳弘、佐藤まりも、田原秀晃、入村達郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Phenotypic and functional diversity of mouse NK cells. (2010)
  • Author(s): 早川芳弘
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(兵庫)
  • Year and Date: 2010-08-23
• [Presentation] 入村達郎腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性 (2010)
  • Author(s): 早川芳弘、佐藤まりも、田原秀晃
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
  • Year and Date: 2010-07-22
• [Presentation] 腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性 (2010)
  • Author(s): 早川芳弘、佐藤まりも、田原秀晃、入村達郎
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: KKRホテル熊本(熊本)
  • Year and Date: 2010-07-22
• [Presentation] 腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性 (2010)
  • Author(s): 早川芳弘、入村達郎
  • Organizer: 第19回日本がん転移学会総会
  • Place of Presentation: 金沢市文化ホール(石川)
  • Year and Date: 2010-06-16
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response. (2009)
  • Author(s): 早川芳弘
  • Organizer: 39th Annual Scientific Meeting, Australasian Society for Immunology
  • Place of Presentation: Cornard Jupiters (Gold Coast, Australia)
  • Year and Date: 2009-12-08
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response (2009)
  • Author(s): 早川芳弘
  • Organizer: 39^<th> Annual Scientific Meeting, Australasian Society for Immunology
  • Place of Presentation: Cornard Jupiters (Gold Coast, Australia)
  • Year and Date: 2009-12-08
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression, and its implication in anti-tumor immune response. (2009)
  • Author(s): 早川芳弘
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2009-12-03
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression, and its implication in anti-tumor immune response (2009)
  • Author(s): 早川芳弘
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-03
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response. (2009)
  • Author(s): 早川芳弘
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-02
• [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response (2009)
  • Author(s): 早川芳弘
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義 (2009)
  • Author(s): 早川芳弘
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 旭川グランドホテル(旭川)
  • Year and Date: 2009-07-23
• [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義 (2009)
  • Author(s): 早川芳弘
  • Organizer: 第18回日本がん転移学会学術集会・総会
  • Place of Presentation: 旭川グランドホテル
  • Year and Date: 2009-07-23
• [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義 (2009)
  • Author(s): 早川芳弘
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州国際会議場(北九州)
  • Year and Date: 2009-06-24
• [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義 (2009)
  • Author(s): 早川芳弘
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2009-06-24
• [Remarks] ホームページ等