Role of Asialoglycoprotein receptor in tumor microenvironment
Project/Area Number |
21890044
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Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
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Research Institution | The University of Tokyo |
Principal Investigator |
HAYAKAWA Yoshihiro The University of Tokyo, 大学院・薬学系研究科, 准教授 (10541956)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
|
Keywords | がん / 転移 / レクチン / 糖鎖 / シグナル伝達 / アシアロ糖蛋白質レセプター / がん転移 / MMP-9 / EGFR / ERK / 糖たんぱく質 / 免疫監視 / NK細胞 |
Research Abstract |
The importance of the interaction between endogenous lectins and glycans on cancer cells has been explored. In this study, we demonstrated that the importance of hepatic asialoglycoprotein receptor (ASGPR), C-type lectin with the preference in the recognition of galactose or N-acetylgalactosamine residue of the counter receptor, in the formation of metastasis of cancer cells.
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Report
(3 results)
Research Products
(30 results)