Analysis of neural circuit formation in the cerebral cortex
| Project/Area Number |
21890046
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKINORI Tokunaga The University of Tokyo, 医科学研究所, 助教 (70549451)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 神経発生 / 神経回路網 / 発生工学 / 神経回路綱 / 再生医療 / エレクトロポーレーション |
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| Research Abstract |
The molecular mechanism of regulating the patterning of neural circuits in developing brain had remained unclear. Therefore we introduced the GFP tracer into developing mouse brain by in utero electroporation to visualize cerebrocortical neuronal cells and the circuits. This method was useful for analyzing the candidate genes concerned with neuronal differentiation and the circuitry formation. By using this method, we identified several functional genes and generated conditional knockout mice.
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Report
(3 results)
Research Products
(17 results)
