| Project/Area Number |
21890047
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORITA Masahiro The University of Tokyo, 医科学研究所, 特任研究員 (50549475)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 遺伝子 / 発現制御 / Deadenylation / マイクロアレイ / 糖尿病 / 脂質代謝 / 国際情報交換 / カナダ / 脂質 |
|---|
| Research Abstract |
Obesity is a life-threatening factor and is often associated with dysregulation of gene expression. The molecular mechanism underlying the development of obesity is largely unknown. In this research project, we showed that CCR4-NOT deadenylase complex plays a key role in energy metabolism. We also identified target mRNAs of CCR4-NOT complex in the liver. Furthermore, we solved the structure of CNOT6L and CNOT7 protein. These findings may be useful to understand the mechanism of the development of obesity.
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