Analysis of the molecular mechanisms controlling self-renewal and differentiation of breast cancer stem cells using systems biological methodology
| Project/Area Number |
21890048
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HINOHARA Kunihiko The University of Tokyo, 医科学研究所, 特任助教 (50549467)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 乳癌 / 癌幹細胞 / GSEA解析 / NF-κB / PI3K/Akt / GSEA |
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| Research Abstract |
We used gene set enrichment analysis (GSEA), which is an analytical method for determining gene expression profiles on the basis of potential pathways and identified that breast cancer cell lines contain a CD44hi/CD24low breast cancer stem cell population with a distinct molecular profile, which includes inflammatory properties. We also identified that NF-κB, one of the main regulator of inflammatory signaling pathway, regulates the self-renewal capacity of breast cancer stem cells.
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Report
(3 results)
Research Products
(17 results)
