The regulation mechanism of TLR3 dependent type II IFN response

• Project/Area Number: 21890049
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: NEGISHI Hideo The University of Tokyo, 大学院・医学系研究科, 助教 (60514297)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,418,000 (Direct Cost: ¥1,860,000、Indirect Cost: ¥558,000); Fiscal Year 2010: ¥1,027,000 (Direct Cost: ¥790,000、Indirect Cost: ¥237,000); Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
• Keywords: TLR / II型IFN / CVB3

Research Abstract

1. TLR3 recognizes the nucleic acid which is produced during CVB3's replication.
2. IRF family transcription factors are activated and induce the type II IFN mRNA in down stream of TLR3 signaling pathway.
3. Type II IFN is produced by CD11b positive macrophages in TLR3 dependent manner.