the behavior and role of naturally occurring and induced regulatory T cells in allergic airway inflammation

• Project/Area Number: 21890057
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: The University of Tokyo
• Principal Investigator: IMAMURA Mitsuru The University of Tokyo, 保健・健康推進本部, 助教 (80529157)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 制御性T細胞 / 気道炎症

Research Abstract

We analyzed the effect of naturally occurring regulatory T cells (nTregs) and induced regulatory T cells (iTregs) in allergic airway inflammation using gene-modified mice. Antigen specific iTregs were induced by airway inflammation, whereas airway inflammation was not changed by iTregs. On the other hand, the transfer of antigen-specific nTregs did not affect airway inflammation.

Research Products

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