Increased efficacy of internal radiotherapy with novel radiosensitizer in malignant neuroendocrine tumor

• Project/Area Number: 21890087
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: KAYANO Daiki Kanazawa University, 附属病院, 助教 (10547152)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 神経芽細胞腫 / 内照射療法

Research Abstract

Intraperitoneal administration of^<131> I-metaiodobenzylguanidine had higher accumulation than intravenous administration of^<131> I-metaiodobenzylguanidine in mice with peritoneal seeding of neuroblastoma. Internal radiotherapy with intravenous administration of^<131> I-metaiodobenzylguanidine did not improve the survival of mice with peritoneal neuroblastoma. On the other hand, internal radiotherapy with intraperitoneal administration of^<131> I-metaiodobenzylguanidine prolonged survival of mice with peritoneal neuroblastoma compared with controls and mice treated with intravenous^<131> I-metaiodobenzylguanidine therapy.