Signaling pathway for interleukin-4 induction in basophils

• Project/Area Number: 21890092
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Shinshu University
• Principal Investigator: ODA Akihisa Shinshu University, 医学部, 研究員 (80547703)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,587,000 (Direct Cost: ¥1,990,000、Indirect Cost: ¥597,000); Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 好塩基球 / アレルギー / IL-4 / PIR-B / 好塩某球 / ITIM / Th2

Research Abstract

Although basophils produce IL-4 in response to IL-3, we discovered that basophils lost IL-3 responsiveness upon activation. PIR-B, the negative regulatory cell surface molecule is involved in the loss of IL-3 responses in activated basophils. In addition, PIR-B also negatively regulates IgG-induced IL-4 production in activated basophils. The inhibitory mechanisms by PIR-B required a cytoplasmic region in an unknown ITIM independent manner.

Research Products

• [Presentation] Paired immunoglobulin-like receptor (PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils. (2010)
  • Author(s): Akihisa Oda, Yuzuru Sakamoto, Toshiyuki Takai、Shigeaki Hida, Shinsuke Taki
  • Organizer: 14th International Congress of Immunology2010
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-08-27
• [Presentation] Basophils sense various external signals with their FcRg-associated cell surface molecule(s) to produce IL-4 in eliciting Th2 responses (2010)
  • Author(s): Shigeaki Hida, Akihisa Oda, Ippei Koshi, Shinsuke Taki
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-08-27
• [Presentation] Paired immunoglobuhin-likereceptor(PIR)-B attenuates IL-3-induced IL-4production inanovel ITIM-independent manner in murine basophils. (2010)
  • Author(s): A.ODA, Y.SAKAMOTO, T.TAKAI, S.HIDA, S.TAKI
  • Organizer: 14^<th>International Congress of Immunology 2010
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-08-27
• [Presentation] Paired immunoglobukin-like receptor (PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils. (2009)
  • Author(s): Yuzuru Sakamoto, Akihisa Oda、Toshiyuki Takai、Shigeaki Hida、Shinsuke Taki
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Presentation] Paired immunoglobulin-like receptor (PIR)-B attenuates IL-3-induced IL-4 production in a novel ITIM-independent manner in murine basophils. (2009)
  • Author(s): 坂本譲、小田朗永
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-12-02
• [Book] 臨床免疫・アレルギー科 (2010)
  • Author(s): 小田朗永、瀧伸介
  • Publisher: 科学評論社
• [Book] 好塩基球におけるIL-4産生誘導シグナルとTh2分化 (2010)
  • Author(s): 小田朗永、瀧伸介
  • Publisher: 科学評論社
• [Remarks] ホームページ等
  • URL: http://www.shinshu-u.ac.jp/graduate/medicine/doctoral/organ-transplant/
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/graduate/medicine/doctoral/m-science/seigyo.html