The relationship between S100-family protein and cell cycle regulator in renal cell cancer
| Project/Area Number |
21890094
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
SUGIYAMA Takayuki Hamamatsu University School of Medicine, 医学部附属病院, 診療助教 (70444346)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,548,000 (Direct Cost: ¥1,960,000、Indirect Cost: ¥588,000)
Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000)
Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
|
|---|
| Keywords | 腎癌 / S100蛋白 / アポトーシス / 腎細胞癌 / S100ファミリー遺伝子 / P53 |
|---|
| Research Abstract |
We examined the S100A2/A4 mRNA level in human renal cell cancer (RCC) cell and resected human kidney specimen. S100A2 mRNA have been elevated in all five RCC cells and S100A4 mRNA were overexpressed in 2 RCC cells. But S100A2 mRNA was low level in human RCC tissue part. S100A2 level were increased in cis-platinum tolerated HEK(human embryonic kidney) cells. We suppose that S100A2 level is regulated by p53-status but S100A4 is not employed by p53.
|
Report
(3 results)
Research Products
(5 results)
