The relationship between S100-family protein and cell cycle regulator in renal cell cancer

• Project/Area Number: 21890094
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUGIYAMA Takayuki Hamamatsu University School of Medicine, 医学部附属病院, 診療助教 (70444346)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,548,000 (Direct Cost: ¥1,960,000、Indirect Cost: ¥588,000); Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000); Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
• Keywords: 腎癌 / S100蛋白 / アポトーシス / 腎細胞癌 / S100ファミリー遺伝子 / P53

Research Abstract

We examined the S100A2/A4 mRNA level in human renal cell cancer (RCC) cell and resected human kidney specimen. S100A2 mRNA have been elevated in all five RCC cells and S100A4 mRNA were overexpressed in 2 RCC cells. But S100A2 mRNA was low level in human RCC tissue part. S100A2 level were increased in cis-platinum tolerated HEK(human embryonic kidney) cells. We suppose that S100A2 level is regulated by p53-status but S100A4 is not employed by p53.

Research Products

• [Presentation] 腎細胞におけるシスプラチン誘導アポトーシスとS100蛋白の反応性の検討 (2010)
  • Author(s): 杉山貴之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] ヒト腎癌細胞株におけるS100ファミリー遺伝子発現の検討 (2010)
  • Author(s): 杉山貴之
  • Organizer: 第98回日本泌尿器科学会学術集会
  • Place of Presentation: 盛岡市民文化ホール(盛岡市)
  • Year and Date: 2010-04-30
• [Presentation] 腎癌細胞株におけるS100A10のプロモーター解析 (2010)
  • Author(s): 高岡直央
  • Organizer: 第19回泌尿器科分子・細胞研究会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-02-19
• [Presentation] ヒト腎癌細胞株におけるS100ファミリー遺伝子発現の検討 (2010)
  • Author(s): 杉山貴之, 他
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
• [Presentation] 腎細胞におけるシスプラチン誘導アポトーシスとS100蛋白の反応性の検討 (2010)
  • Author(s): 杉山貴之, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市