| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Research Abstract |
We found that Ret Finger Protein (RFP) catalyze the ubiquitination of Lamin A. We could not prove the degradation of Lamin A by ubiquitination as initially envisioned, however, we found that both RFP and Lamin A can positively regulate cancer cell migration. Therefore, our findings indicate another possibility that RFP regulates the Lamin A's function through its ubiquitination. Since there is no report that the mechanism regulates Lamin A through ubiquitination, our results preface the novel investigation of regulation of Lamin A.
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