| Project/Area Number |
21890099
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
CHINATSU Arima Nagoya University, 大学院・医学系研究科, COE特任助教 (00534843)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
|---|
| Keywords | 肺癌 / マイクロRNA / マイクロアレイ / 肺腺癌 / mRNAマイクロアレイ / miRNAマイクロアレイ |
|---|
| Research Abstract |
The aim of this study is to identify networks composed of mRNAs and miRNAs that show distinctive abnormality in the control of expression in the development of lung cancer. Thus, we extracted genes and miRNAs that are likely to directly regulate each other. As a result, we have found 10 pairs of miRNAs and their potential direct downstreams as well as 12 pairs of transcription factors and miRNAs of their potential targets. They included previously reported pairs including miR-29c and DNMT3A/DNMT3B as well as E2F8 and miR-18a. The regulatory interactions between the miRNAs and the coding genes are being experimentally validated.
|
