| Project/Area Number |
21890100
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
SATO Yoshiaki Nagoya University, 医学部附属病院, 助教 (30435862)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,535,000 (Direct Cost: ¥1,950,000、Indirect Cost: ¥585,000)
Fiscal Year 2010: ¥1,196,000 (Direct Cost: ¥920,000、Indirect Cost: ¥276,000)
Fiscal Year 2009: ¥1,339,000 (Direct Cost: ¥1,030,000、Indirect Cost: ¥309,000)
|
|---|
| Keywords | 臍帯血 / 周産期脳障害 / 臍帯血幹細胞 |
|---|
| Research Abstract |
It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we have performed basic experiments for developing a novel therapy with human umbilical cord blood cells (HUCB), which is most ideal source of stem cells for perinatal brain injuries. After establishing a perinatal HI rat model, we evaluated the effect of administration of HUCB on perinatal HIE. We injected HUSB peritoneally after hypoxic-ischemic insult. The injected HUSB migrated into the brain, and tended to exert the anti-apoptotic and anti-oxidative effect, and increase the cell proliferation.
|
