Novel bone regeneration treatment using by dental pulp stem cells, growth factors, And the extracellular matrix modified scaffold

• Project/Area Number: 21890102
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nagoya University
• Principal Investigator: YOSHIMI Ryoko Nagoya University, 医学部附属病院, 医員 (40547543)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥1,066,000 (Direct Cost: ¥820,000、Indirect Cost: ¥246,000); Fiscal Year 2009: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
• Keywords: 歯髄 / 乳歯 / 再生医療 / 幹細胞 / 組織工学

Research Abstract

Dental pulp stem cells (DPSCs) and cryopreserved DPSCs were nearly equal to bone-marrow-derived mesenchymal stem cells in cell proliferation and pluripotency. Both cells showed well-formed bone regeneration by transplantation with the extracellular matrix modified scaffold in bone defects. It was suggested that DPSCs were useful cell source for bone regeneration using tissue engineering technology.

Research Products

• [Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology (2010)
  • Author(s): Yamada Y, Nakamura S, Ito K, Sugito T, Yoshimi R, Nagasaka T, Ueda M
  • Journal Title: Tissue Eng Part A Vol.16 Pages: 1891-1900
  • Peer Reviewed
• [Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology. (2010)
  • Author(s): Yamada, Y
  • Journal Title: Tissue Eng Part A. Volume: 16 Pages: 1891-1900
  • Peer Reviewed
• [Journal Article] A feasibility of useful cell-based therapy by bone regeneration with deciduous tooth stem cells, dental pulp stem cells, or bone-marrow-derived mesenchymal stem cells for clinical study using tissue engineering technology. (2010)
  • Author(s): Yamada, Y
  • Journal Title: Tissue Eng Part A. (Epub ahead of print)
  • Peer Reviewed
• [Presentation] 乳歯。永久歯由来歯髄幹細胞による顎顔面領域再生への可能性 (2009)
  • Author(s): 山田陽一、伊藤憲治、中村さやか、片桐渉、杉戸孝行、吉見涼子、西野雄大、日比英晴、上田実
  • Organizer: 第54回日本口腔外科学会総会
  • Year and Date: 2009-10-10
• [Presentation] 乳歯歯髄幹細胞による皮膚創傷治癒効果の検討 (2009)
  • Author(s): 西野雄大、山田陽一、伊藤憲治、中村さやか、岡部一登、高後友之、吉見涼子、原憲史、梅村恵理、上田実
  • Organizer: 第54回日本口腔外科学会総会
  • Year and Date: 2009-10-10
• [Presentation] 乳歯・永久歯由来歯髄幹細胞による顎顔面領域再生への可能性 (2009)
  • Author(s): 山田陽一
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10
• [Presentation] 乳歯歯髄幹細胞による皮膚創傷治癒効果の検討 (2009)
  • Author(s): 西野雄大
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10