| Project/Area Number |
21890110
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
NAGAI Yoshio Shiga University of Medical Science, 医学部, 医員 (90402718)
|
|---|
| Research Collaborator |
USHIO Masateru 滋賀医科大学, 医学部, 大学院生
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
|---|
| Keywords | 果糖 / 糖鎖 / メタボリックシンドローム / 栄養 |
|---|
| Research Abstract |
The impact analysis using mouse liver tissue of high fructose feeding, revealed that O-GlcNAc proteins were increased after meal ingestion. These data suggest that increased hexosamine pathway might be associated with the development of metabolic syndrome. Furthermore, fructose may activate a transcription factor, ChREBP which was known to respond to glucose.
|
