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Exploring the kinase-independent role of IKKβ

Research Project

Project/Area Number 21890115
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKyoto University

Principal Investigator

ASHIDA Noboru  Kyoto University, 医学研究科, 助教 (00538978)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords炎症 / 循環器
Research Abstract

We have identified several proteins which physically interact with IKKβ and they are possibly regulated by it in kinase-independent manner. Also we have found some proteins which have been reported to have close connection with atherosclerosis or cancer are regulated by some anti-inflammatory drugs.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] IKK β regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.2011

    • Author(s)
      Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Shi Yin Foo, Matthew Coggins, Joel A. Spencer, Parisa Zamiri, Dongxiao Shen, Ling Li, Tracey Sciuto, Ann Dvorak, Robert E. Gerszten, Charles P. Lin, Michael Karin, Anthony Rosenzweig.
    • Journal Title

      Corresponding Authors : Anthony Rosenzweig and Noboru Ashida doi:10.1038/ncomms1317

      Pages: 2-318

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Exploring the role of IKKβ2010

    • Author(s)
      芦田昇
    • Organizer
      動脈硬化若手研究会
    • Place of Presentation
      クラブ関東:東京都千代田区丸ノ内1-3-1-19F
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] IKK β regulates Akt activation in kinase-independent manner in endothelial cells2009

    • Author(s)
      Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Joel A.Spencer, Parisa Zamiri, Ling Li, Robert E.Gerszten, Charles P.Lin, Michael Karin, Anthony Rosenzweig, Masayuki Yokode.
    • Organizer
      第41回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      於下関メッセ
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] IKKβ regulates Akt activation in kinase-independent manner in endothelial cells2009

    • Author(s)
      芦田昇
    • Organizer
      第41回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      海峡メッセ下関
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp/kyoto-u.ac.jp/~rinsho/research/SRP/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~rinsho/research/SRP/research1/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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