Exploring the kinase-independent role of IKKβ

• Project/Area Number: 21890115
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Kyoto University
• Principal Investigator: ASHIDA Noboru Kyoto University, 医学研究科, 助教 (00538978)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000); Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000); Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
• Keywords: 炎症 / 循環器

Research Abstract

We have identified several proteins which physically interact with IKKβ and they are possibly regulated by it in kinase-independent manner. Also we have found some proteins which have been reported to have close connection with atherosclerosis or cancer are regulated by some anti-inflammatory drugs.

Research Products

• [Journal Article] IKK β regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. (2011)
  • Author(s): Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Shi Yin Foo, Matthew Coggins, Joel A. Spencer, Parisa Zamiri, Dongxiao Shen, Ling Li, Tracey Sciuto, Ann Dvorak, Robert E. Gerszten, Charles P. Lin, Michael Karin, Anthony Rosenzweig.
  • Journal Title: Corresponding Authors : Anthony Rosenzweig and Noboru Ashida doi:10.1038/ncomms1317 Pages: 2-318
  • Peer Reviewed
• [Presentation] Exploring the role of IKKβ (2010)
  • Author(s): 芦田昇
  • Organizer: 動脈硬化若手研究会
  • Place of Presentation: クラブ関東:東京都千代田区丸ノ内1-3-1-19F
  • Year and Date: 2010-11-27
• [Presentation] IKK β regulates Akt activation in kinase-independent manner in endothelial cells (2009)
  • Author(s): Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Joel A.Spencer, Parisa Zamiri, Ling Li, Robert E.Gerszten, Charles P.Lin, Michael Karin, Anthony Rosenzweig, Masayuki Yokode.
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 於下関メッセ
  • Year and Date: 2009-07-17
• [Presentation] IKKβ regulates Akt activation in kinase-independent manner in endothelial cells (2009)
  • Author(s): 芦田昇
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 海峡メッセ下関
  • Year and Date: 2009-07-17
• [Remarks]
  • URL: http://www.kuhp/kyoto-u.ac.jp/~rinsho/research/SRP/index.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~rinsho/research/SRP/research1/index.html