Regulation of transcription factors and neuronal development by necdin-Sirt1 complex

• Project/Area Number: 21890123
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: HASEGAWA Koichi Osaka University, たんぱく質研究所, 助教 (20546783)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,392,000 (Direct Cost: ¥1,840,000、Indirect Cost: ¥552,000); Fiscal Year 2010: ¥1,092,000 (Direct Cost: ¥840,000、Indirect Cost: ¥252,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: エネルギー代謝 / 摂食 / 肥満 / 体温調節 / アセチル化 / 視床下部 / 脳神経疾患 / 神経科学 / 発生、分化 / 脳、神経

Research Abstract

Necdin is a positive regulator of Sirt1 protein deacetylase. In this study, I focused Foxo1 that is related for feeding. Necdin-Sirt1 complex deacetylased Foxo1 and modified thermoregulation through controlling neuropeptides and thyroid hormones.

Research Products

• [Journal Article] Neural stem cell-like gene expression in a mouse ependymoma cell line transformed by human BK polyomavirus (2010)
  • Author(s): Takako Aizawa*, Koichi Hasegawa*, Tsuyoshi Ohkumo, Seiichi Haga, Kazuhiko Ikeda, Kazuaki Yoshikawa
  • Journal Title: Cancer Science 102(1) Pages: 122-129
  • NAID: 10029288727
  • Peer Reviewed
• [Journal Article] Necdin Promotes Tangential Migration of Neocortical Interneurons from Basal Forebrain (2010)
  • Author(s): Takaaki Kuwajima*, Koichi Hasegawa*, Kazuaki Yoshikawa
  • Journal Title: The Journal of Neuroscience 30(10) Pages: 3709-3714
  • Peer Reviewed
• [Journal Article] Necdin promotes tangential migration of neocortical interneuron from basal forebrain (2010)
  • Author(s): Takaaki Kuwajima, et al.
  • Journal Title: The Journal of Neuroscience Volume: 30 Pages: 3709-3714
  • Peer Reviewed
• [Journal Article] Neural stem cell-like gene expression in a mouse ependymoma cell line transformed by human BK polyomavirus (2010)
  • Author(s): Takako Aizawa, et al.
  • Journal Title: Cancer Science Volume: 102 Pages: 122-129
  • Peer Reviewed
• [Presentation] Necdin enhances Sirt1-dependent deacetylation of Foxo1 to control hypothalamic thermoregulation (2010)
  • Author(s): 長谷川孝一、吉川和明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Necdin controls proliferation of white adipocyte progenitors (2010)
  • Author(s): 藤原一志郎、長谷川孝一、吉川和明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Necdin enhances Sirt1-dependent deacetylation of Foxo1 to control hypothalamic thermoregulation (2010)
  • Author(s): 長谷川孝一、吉川和明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-10
• [Presentation] Necdin serves as Nse3 in mammalian Smc5/6 complex (2010)
  • Author(s): 吉田直史、長谷川孝一、吉川和明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Necdin regulates neural stem cell proliferation during postnatal development (2010)
  • Author(s): 橋長秀典、長谷川孝一、吉川和明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Necdin regulates Foxo1acetylation via Sirt1 in mouse hypothalamus Neuroscience 2010 (2010)
  • Author(s): 長谷川孝一, 吉川和明
  • Organizer: 40th Annual Meeting
  • Place of Presentation: San Diego CA
  • Year and Date: 2010-11-15
• [Presentation] Necdin regulates Foxo1 acetylation via Sirt1 in mouse hypothalamus (2010)
  • Author(s): Koichi Hasegawa, Kazuaki Yoshikawa
  • Organizer: Neuroscience 2010 40^<th> Annual Meeting
  • Place of Presentation: San Diego Convention Center (USA)
  • Year and Date: 2010-11-15
• [Presentation] Neural stem cell proliferation is regulated through interaction between necdin and Bmi1 polycomb complex protein(神経幹細胞の増殖はnecdinとポリコーム複合体タンパク質Bmi1の相互作用によって制御されている) (2010)
  • Author(s): 南出良平、長谷川孝一、大雲剛志、吉川和明
  • Organizer: 第53回日本神経化学会大会(Neuro2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Necdin-Sirt1 complex regulates hypothalamic Foxo1 acetylation to control energy homeostasis(Necdin-Sirt1 複合体による視床下部Foxo1のアセル化の制御) (2010)
  • Author(s): 長谷川孝一、吉川和明
  • Organizer: 第53回日本神経化学会大会(Neuro2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Epigenetic regulation of necdin gene expression during neural development(神経分化におけるnecdin遺伝子のエピジェティックな発現制御) (2010)
  • Author(s): 大雲剛志、長谷川孝一、藤原一志郎、吉川和明
  • Organizer: 第53回日本神経化学会大会(Neuro2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Necdin-Sirt1 complex regulates hypothalamic Foxo1 acetylation to control energy homeostasis(Necdin-Sirt1複合体による視床下部Foxo1のアセチル化の制御) (2010)
  • Author(s): 長谷川孝一、吉川和明
  • Organizer: 第53回日本神経化学会大会(Neuro2010)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-09-02
• [Presentation] Regulation of Foxo1 acetylation by neuronal necdin-Sirt1 complex (2010)
  • Author(s): 長谷川孝一, 吉川和明
  • Organizer: The Joint Symposium of the 5th International Symposium of Institute Network
  • Place of Presentation: Kanazawa
  • Year and Date: 2010-06-24
• [Presentation] Regulation of Foxo1 acetylation by neuronal necdin-Sirt1 complex (2010)
  • Author(s): Koichi Hasegawa, Kazuaki Yoshikawa
  • Organizer: The Joint Symposium of the 5th International Symposium of Institute Network
  • Place of Presentation: KKR Hotel Kanazawa(石川県)
  • Year and Date: 2010-06-24
• [Presentation] Acetylation status of transcription factors is regulated by neuronal necdin-Sirt1 complex(ニューロンにおけるnecdin-Sirt1複合体による転写因子アセチル化状態の制御) (2009)
  • Author(s): 長谷川孝一
  • Organizer: Institute for Protein Research Retreat
  • Place of Presentation: Hyogo
  • Year and Date: 2009-11-17
• [Presentation] Regulation of necdin expression by DNAmethylation during neural development(神経発生におけるnecdin遺伝子のメチル化による発現調節) (2009)
  • Author(s): 大雲剛志、蔡宗樺、長谷川孝一、吉川和明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] The necdin-Sirt1complex deacetylates Foxo1 to suppress its transcriptional activity (Necdin-Sirt1複合体はFoxo1を脱アセチル化して転写活性を抑制する) (2009)
  • Author(s): 長谷川孝一、吉川和明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Necdin regulates adipocyte differentiation via mitotic clonal expansion(Necdinによる脂肪細胞分化の制御機構の解析) (2009)
  • Author(s): 藤原一志郎、長谷川孝一、大雲剛志、吉川和明
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] Necdin-Sirt1複合体はFoxo1を脱アセチル化して転写活性を抑制する (2009)
  • Author(s): 長谷川孝一、川原知浩、吉川和明
  • Organizer: 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] Regulated expression of MAGE family genes during neural development (2009)
  • Author(s): 大雲剛志、蔡宗樺、長谷川孝一、吉川和明
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 群馬
  • Year and Date: 2009-06-22
• [Remarks] 大阪大学 蛋白質研究所 蛋白質高次機能学研究部門 神経発生制御研究室ホームページ
  • URL: http://www.protein.osaka-u.ac.jp/regulation/index_jap.html
• [Remarks]
  • URL: http://www.protein.osaka-u.ac.jp/regulation/publication.html