Analysis of molecular mechanism of arteriovenous patterning

• Project/Area Number: 21890124
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Osaka University
• Principal Investigator: KIDOYA Hiroyasu Osaka University, 微生物病研究所, 助教 (00543886)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,821,000 (Direct Cost: ¥2,170,000、Indirect Cost: ¥651,000); Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 血管新生 / 血管再生 / 組織再生 / 再生医療 / 腫瘍血管 / 発生

Research Abstract

In this study, we analyze the apelin/APJ system to establish the new method of effective neovascularization therapy. In the skin of mouse embryo, apelin is expressed in artery and APJ is expressed in vein. Moreover we found that apelin produced by artery effect to APJ in vein and contribute to arteriovenous patterning.

Research Products

• [Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. (2011)
  • Author(s): Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M.
  • Journal Title: Proceedings of the National Academy of Sciences 108巻 Pages: 1451-1455
  • Peer Reviewed
• [Journal Article] Apelin induces enlarged and non-leaky blood vessels for functional recovery from ischemia. (2011)
  • Author(s): Kidoya H, Naito H, Takakura N.
  • Journal Title: Blood 115巻 Pages: 3166-3174
  • Peer Reviewed
• [Journal Article] Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. (2011)
  • Author(s): Kidoya H, Naito H, Takakura N.
  • Journal Title: Blood Volume: 115 Pages: 3166-3174
  • Peer Reviewed
• [Journal Article] Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. (2011)
  • Author(s): Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 108 Pages: 1451-1455
  • Peer Reviewed
• [Journal Article] Maturation of blood vessels by haematopoietic stem cells and progenitor cells : involvement of apelin/APJ and angiopoietin/Tie2 interactions in vessel caliber size regulation. (2009)
  • Author(s): Takakura N, Kidoya H.
  • Journal Title: Thrombosis and Haemostasis 101巻 Pages: 999-1005
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population. (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, Takakura N.
  • Journal Title: The Journal of Biochemistry 145巻 Pages: 653-659
  • NAID: 10025589080
  • Peer Reviewed
• [Journal Article] Maturation of blood vessels by haematopoietic stem cells and progenitor cells : involvement of apelin/APJ and angiopoietin/Tie2 interactions invessel caliber size regulation. (2009)
  • Author(s): Takakura N, Kidoya H.
  • Journal Title: Thrombosis and Haemostasis 101 Pages: 999-1005
  • Peer Reviewed
• [Journal Article] Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population. (2009)
  • Author(s): Naito H, Kidoya H, Sato Y, Takakura N.
  • Journal Title: The Journal of Biochemistry 145 Pages: 653-659
  • NAID: 10025589080
  • Peer Reviewed
• [Journal Article] Apelin induces enlarged and non-leaky blood vessels for functional recovery form ischemia
  • Author(s): Kidoya H, Naito H, Takakura N.
  • Journal Title: Blood (印刷中)
  • Peer Reviewed
• [Presentation] Role of microRNAs for tumor angiogenesis and endothelial function (2010)
  • Author(s): 木戸屋浩康
  • Organizer: 第18回日本血管生物医学会学術集会/The 8th Korea-Japan Joint Symposium on Vascular Biology work
  • Place of Presentation: 大阪府大阪市 梅田スカイビル(招待講演)
  • Year and Date: 2010-12-02
• [Presentation] Role of microRNAs for tumor angiogenesis and endothelial function (2010)
  • Author(s): 木戸屋浩康
  • Organizer: 第18回日本血管生物医学会学術集会/The 8th Korea-Japan Joint Symposium on Vascular Biology work
  • Place of Presentation: 大阪府大阪市梅田スカイビル(招待講演)
  • Year and Date: 2010-12-02
• [Presentation] 腫瘍血管形成を制御する新規標的miRNAの同定と機能解析 (2010)
  • Author(s): 木戸屋浩康
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪府大阪市 リーガロイヤルホテル
  • Year and Date: 2010-09-23
• [Presentation] 腫瘍血管形成を制御する新規標的miRNAの同定と機能解析 (2010)
  • Author(s): 木戸屋浩康
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪府大阪市リーガロイヤルホテル
  • Year and Date: 2010-09-23
• [Presentation] Role of specific microRNAs for tumor endothelial function and angiogenesis. 'Angiogenesis' (2010)
  • Author(s): 木戸屋浩康
  • Organizer: Molecular Mechanisms and Functional Interactions
  • Place of Presentation: Kloster Seeon (Germany)
  • Year and Date: 2010-09-19
• [Presentation] Role of specific microRNAs for tumor endothelial function and angiogenesis. (2010)
  • Author(s): Hiroyasu Kidoya
  • Organizer: 'Angiogenesis' : Molecular Mechanisms and Functional Interactions.
  • Place of Presentation: Kloster Seeon (Germany)
  • Year and Date: 2010-09-19
• [Presentation] The possibility of the revascularization therapy by a neovascular maturation factor apelin (2010)
  • Author(s): 木戸屋浩康
  • Organizer: The 5th international symposium of institute network
  • Place of Presentation: 石川県金沢市KKI ホテル
  • Year and Date: 2010-06-24
• [Presentation] The possibility of the revascularization therapy by a neovascular maturation factor apelin. (2010)
  • Author(s): Hiroyasu Kidoya
  • Organizer: The 5th international symposium of institute network.
  • Place of Presentation: 石川県金沢市KKIホテル
  • Year and Date: 2010-06-24
• [Presentation] Apelinによる腫瘍血管成熟化は癌免疫療法の効果を改善する (2009)
  • Author(s): 木戸屋浩康
  • Organizer: 血管生物医学会
  • Place of Presentation: 東京都文京区東京大学
  • Year and Date: 2009-10-09
• [Presentation] Apelinによる腫瘍血管成熟化は癌免疫療法の効果を改善する (2009)
  • Author(s): 木戸屋浩康
  • Organizer: 第17回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-09
• [Book] 細胞工学11月号1 (2011)
  • Author(s): 木戸屋浩康
  • Publisher: 秀潤社
• [Book] 細胞工学11月号 (2011)
  • Author(s): 木戸屋浩康
  • Publisher: 秀潤社
• [Remarks] ホームページ等
  • URL: http://st.biken.osaka-u.ac.jp/
• [Remarks]
  • URL: http://st.biken.osaka-u.ac.jp/
• [Remarks]
  • URL: http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspi/RX0011D.asp?UNO=19906&page=