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Analysis of the induction and activation of intestinal Th17 cells

Research Project

Project/Area Number 21890127
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe University of Tokyo (2010)
Osaka University (2009)

Principal Investigator

ATARASHI KOJI  The University of Tokyo, 大学院・医学系研究科, 特任助教 (60546787)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
KeywordsTh17細胞 / Treg細胞 / 腸内細菌 / 炎症性腸疾患 / 制御性T細胞 / クロストリジウム / TH17細胞 / 粘膜免疫 / SFB
Research Abstract

Th17 cells, one of T helper subsets, secrete interleukin-17 (IL-17), IL-17F, and IL-22 and have significant roles in protecting the host from bacterial and fungal infections, as well as autoimmune diseases. I have demonstrated that Th17 cells are abundant in intestinal mucosa and Th17 cell accumulation in gut is induced by segmented filamentous bacteria (SFB). At the same time, the accumulation of regulatory T cells (Tregs) in gut is mediated by Clostridium species.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species.2011

    • Author(s)
      Atarashi K, et al.
    • Journal Title

      Science 331(6015)

      Pages: 337-341

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microbiotal influence on T cell subset development2011

    • Author(s)
      Atarashi K, Umesaki Y Honda K.
    • Journal Title

      Seminars in immunology

      Volume: 印刷中(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species2011

    • Author(s)
      Atarashi K., et. al.
    • Journal Title

      Science

      Volume: 331 Pages: 337-341

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of lamina propria Th17 cells by intestinal commensal bacteria.2010

    • Author(s)
      Atarashi K, Tanoue T, Honda K.
    • Journal Title

      Vaccine 28(50)

      Pages: 8036-8038

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of lamina propria Th17 cells by intestinal commensal bacteria2010

    • Author(s)
      Atarashi K, Tanoue T, Honda K.
    • Journal Title

      Vaccine

      Volume: 28 Pages: 8036-8038

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria.2009

    • Author(s)
      Ivanov II, Atarashi K, et al.
    • Journal Title

      Cell 139(3)

      Pages: 485-498

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria2009

    • Author(s)
      Ivanov II, Atarashi K, et al.
    • Journal Title

      Cell 139

      Pages: 485-498

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Th17 cell differentiation in the intestinal lamina propria.2009

    • Author(s)
      Atarashi K, Takeda K, Honda K
    • Journal Title

      Inflammation and Regeneration 29

      Pages: 263-269

    • NAID

      10026093948

    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of colonic regulatory T cells by Clostridium species2010

    • Author(s)
      新幸二
    • Organizer
      第14回国際免疫会議
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of colonic regulatory T cells by Clostridium species2010

    • Author(s)
      Atarashi K, Tanoue T, Honda K
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際展示場(兵庫県)
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immune regulation by intestinal microflora2009

    • Author(s)
      Kenya Honda
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腸内細菌によるTh17細胞誘導機構2009

    • Author(s)
      新幸二
    • Organizer
      日本食品免疫学会設立5周年記念学術大会
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2009-05-27
    • Related Report
      2010 Final Research Report
  • [Book] ATPが腸管粘膜固有層のTh17細胞を誘導する2009

    • Author(s)
      新幸二
    • Publisher
      日本メディカルセンター(INTESTINE)
    • Related Report
      2010 Final Research Report
  • [Book] ATPが腸管粘膜固有層のTh17細胞を誘導する2009

    • Author(s)
      新幸二、竹田潔
    • Total Pages
      2
    • Publisher
      日本メディカルセンター(INTESTINE)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.immunol.m.u-tokyo.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 制御性T細胞の増殖または集積を誘導する作用を有する組成物2010

    • Inventor(s)
      本田賢也、新幸二、伊藤喜久治
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2010-129134
    • Filing Date
      2010-06-04
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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