Research Project
Grant-in-Aid for Research Activity Start-up
Paclitaxel-resistant ovarian cancer cells showed the activation of Akt and significantly higher levels of Akt2 expression compared with paclitaxel-sensitive cells. An HIF-2α expression was also higher in paclitaxel-resistant cells than in paclitaxel-sensitive cells.We next examined the significance of Akt2 in paclitaxel-resistant in vivo tumor growth by selectively inhibiting Akt2. An siRNA targeting Akt2 inhibited ovarian tumor growth in nude mice. These results indicated molecular target treatment against either Akt2 or HIF-2α would be useful for the paclitaxel-resistant ovarian cancer.
All 2011 2010 2009
All Journal Article (5 results) (of which Peer Reviewed: 1 results)
Cell Cycle. in press
Mol Cancer Ther 9
Pages: 2411-2422
Ann N Y Acad Sci. 1177
Pages: 198-204
Clin Cancer Res. 15
Pages: 5404-5413