| Project/Area Number |
21890133
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAGUCHI Mikiyo Osaka University, 歯学部附属病院, 医員 (30523089)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,574,000 (Direct Cost: ¥1,980,000、Indirect Cost: ¥594,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,339,000 (Direct Cost: ¥1,030,000、Indirect Cost: ¥309,000)
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| Keywords | 歯学 / バイオフィルム / 抗菌剤 / ポルフィロモナス ジンジバリス / 菌体外マトリックス / Porphyromonas gingivalis / グルコン酸クロルヘキシジン / 塩化セチルピリジニウム / 走査型電子顕微鏡 / 透過型電子顕微鏡 / ホリフィロモナスジンジバリス / 共焦点レーザー顕微鏡 |
|---|
| Research Abstract |
In this study, I showed that chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC) were effective against Porphyromonas gingivalis cells in biofilm, but extracellular matrix remained in biofilm after CHX and CPC application. In addition, extracellular matrix remained after CHX application was difficult to eliminate mechanically, suggesting that remaining extracellular matrix provides a scaffold for biofilm reformation.
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