Application of Polyphasic Calcium Phosphates to Direct Pulp Capping

• Project/Area Number: 21890134
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: KIBA Wakako Osaka University, 歯学部附属病院, 医員 (10523087)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,509,000 (Direct Cost: ¥1,930,000、Indirect Cost: ¥579,000); Fiscal Year 2010: ¥1,209,000 (Direct Cost: ¥930,000、Indirect Cost: ¥279,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯学 / 覆髄 / リン酸カルシウム / dentin bridge / 象牙芽細胞 / ハイドロキシアパタイト / 硬組織誘導

Research Abstract

Poly-CaP is effective to induce hard tissue formation because of its Ca-releasing property from the soluble calcium phosphates phase on the surface. Poly-CaP was also found to support proliferation and to promote differentiation of odontblast-like cells on its surface. Activation of odontoblastic function is suggested to be involved in the effectiveness of Poly-CaP to induce hard tissue formation. Impregnation of resin into etched HAp surface, with production of no gap at the bonding interface, was seen for all adhesives. These results suggest that its usefulness for direct pulp capping.

Research Products

• [Journal Article] Efficacy of polyphasic calcium phosphates as a direct pulp capping material. (2010)
  • Author(s): Kiba W, Imazato S, Takahashi Y, Yoshioka S, Ebisu S, Nakano T.
  • Journal Title: J Dent. 38 Pages: 828-837
  • Peer Reviewed
• [Journal Article] Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials. (2010)
  • Author(s): Imazato S, Horikawa D, Takeda K, Kiba W, Izutani N, Yoshikawa R, Hayashi M, Ebisu S, Nakano T.
  • Journal Title: Dent Mater J. 29 Pages: 341-346
  • NAID: 10026470432
  • Peer Reviewed
• [Journal Article] Efficacy of polyphasic calcium phosphates as a direct pulp capping material. (2010)
  • Author(s): Wakako Kiba, et al
  • Journal Title: Journal of Dentistry Volume: 38 Pages: 827-837
  • Peer Reviewed
• [Journal Article] Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials. (2010)
  • Author(s): Satoshi Imazato, et al.
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 341-346
  • Peer Reviewed
• [Presentation] 多相性リン酸カルシウムの直接覆髄法への応用-象牙芽細胞様細胞を用いた評価- (2010)
  • Author(s): 騎馬和歌子, 今里聡, 恵比須繁之, 中野貴由, 斎藤隆史
  • Organizer: 日本歯科保存学会2010年度秋季学術大会(第133回)
  • Place of Presentation: 岐阜市長良川国際会議場
  • Year and Date: 2010-10-29
• [Presentation] 多相性リン酸カルシウムの直接覆髄法への応用-象牙芽細胞様細胞を用いた評価- (2010)
  • Author(s): 騎馬和歌子, ら
  • Organizer: 第133回日本歯科保存学会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-10-29
• [Presentation] Evaluation of effects of poly-phasic calcium phosphates on odontoblast-like cells (2010)
  • Author(s): Kiba W, Imazato S, Takeda K, Takahashi Y, Ebisu S, Nakano T
  • Organizer: IADR
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 2010-07-16
• [Presentation] Evaluation of effects of poly-phasic calcium phosphates on odontoblast-like cells (2010)
  • Author(s): Wakako Kiba, et al.
  • Organizer: 88^<th> IADR
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 2010-07-16