| Project/Area Number |
21890141
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kobe University |
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Principal Investigator |
YASUFUKU Tomihiko Kobe University, 大学院・医学研究科, 医学研究員 (10533771)
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| Research Collaborator |
SHIGEMURA Katsumi 神戸大学, 大学院・医学研究科, 医学研究員 (00457102)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,145,000 (Direct Cost: ¥1,650,000、Indirect Cost: ¥495,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | 薬剤排出ポンプ / 大腸菌 / 抗菌薬耐性 / efflux pump |
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| Research Abstract |
Efflux system overexpression is reported to contribute to Escherichia coli resistance to several antibiotics. This study investigated the correlation of antibiotic susceptibilities with overexpression of the efflux pump genes. We examined the expression level of efflux pump genes of E. coli. Significant relationships were demonstrated between overexpression of efflux pump genes and antibiotic resistance. This study demonstrated that increased expression of efflux pump genes can lead to fluoroquinolone resistance in E. coli causative UTI. These results contribute to our knowledge of the efflux system and raise the possibility of developing new agents such as efflux pump inhibitors (EPIs) to antibiotic-resistant E. coli.
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