Prediction of the treatment effect of chemotherapy for the patients with hepatocellular carcinoma

• Project/Area Number: 21890146
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Okayama University
• Principal Investigator: NOUSO Kazuhiro Okayama University, 大学院・医歯薬学総合研究科, 准教授 (10314668)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 肝癌 / 化学療法 / 糖鎖 / サイトカイン / 肝細胞癌

Research Abstract

Recently, several anti-cancer drugs for the treatment of hepatocellular carcinoma were developed and the survival of the patients was prolonged. However, the effect and side effect of the drugs were different from the patient to patient. In this experiment, we reported that over-expression of several cytokines related to angiogenesis and down regulation of certain glycans were correlated with poor response to the drugs and with increased side effects.

Research Products

• [Journal Article] Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. (2011)
  • Author(s): Nakanishi Y, Shiraha H, Nishina SI, Tanaka S, Matsubara M, Horiguchi S, Iwamuro M, Takaoka N, Uemura M, Kuwaki K, Hagihara H, Toshimori J, Ohnishi H, Takaki A, Nakamura S, Kobayashi Y, Nouso K, Yagi T, Yamamoto K.
  • Journal Title: BMC Cancer. 11(1) Pages: 3-3
  • NAID: 120005053306
  • Peer Reviewed
• [Journal Article] Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis. (2011)
  • Author(s): Nakanishi Y
  • Journal Title: BMC Cancer Volume: 11
  • Peer Reviewed
• [Journal Article] Prognostic model for hepatocellular carcinoma with time-dependent factors. (2011)
  • Author(s): Kuwaki K
  • Journal Title: Acta Medica Okayama Volume: 65 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Prognostic importance of fucosylated alpha-fetoprotein in hepatocellular carcinoma patients with low alpha-fetoprotein. (2011)
  • Author(s): Nouso K
  • Journal Title: J Gastroenterol Hepatol Volume: 16-Mar
  • Peer Reviewed
• [Journal Article] Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine. (2011)
  • Author(s): Kobashi H
  • Journal Title: Hepatol Res Volume: 21-Mar
  • Peer Reviewed
• [Journal Article] Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma. (2010)
  • Author(s): H agihara H, Nouso K, Kobayashi Y, Iwasaki Y, Nakamura S, Kuwaki K, Toshimori J, Miyatake H, Ohnishi H, Shiraha H, Yamamoto K.
  • Journal Title: Int J Clin Oncol.
  • NAID: 10029526889
  • Peer Reviewed
• [Journal Article] Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma. (2010)
  • Author(s): Ohnishi H, Sakaguchi K, Nouso K, Kobayashi Y, Nakamura S, Tanaka H, Miyake Y, Shoji B, Iwadou S, Shiratori Y.
  • Journal Title: Hepatol Int. 4(3) Pages: 562-568
  • Peer Reviewed
• [Journal Article] Clinical trial : oral zinc in hepatic encephalopathy. (2010)
  • Author(s): Takuma Y, Nouso K, Makino Y, Hayashi M, Takahashi H.
  • Journal Title: Aliment Pharmacol Ther. 32(9),4(3)
  • Peer Reviewed
• [Journal Article] Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease. (2010)
  • Author(s): Shoji B, Ikeda F, Fujioka SI, Kobashi H, Yasunaka T, Miyake Y, Shiraha H, Takaki A, Nouso K, Iwasaki Y, Yamamoto K.
  • Journal Title: J Gastroenterol 45(11) Pages: 1172-1182
  • NAID: 10027699942
  • Peer Reviewed
• [Journal Article] Time-dependent analysis of predisposing factors for the recurrence of hepatocellular carcinoma. (2010)
  • Author(s): Iwadou S, Nouso K, Kuwaki K, Kobayashi Y, Nakamura S, Tanaka H, Miyoshi K, Ohnishi H, Miyake Y, Shiraha H, Iwasaki Y, Shiratori Y, Yamamoto K.
  • Journal Title: Liver Int. 30(7) Pages: 1027-1032
  • Peer Reviewed
• [Journal Article] Preoperative estimation of remnant hepatic function using fusion images obtained by (99m)Tc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography. (2010)
  • Author(s): Yumoto Y, Yagi T, Sato S, Nouso K, Kobayashi Y, Ohmoto M, Yumoto E, Nagaya I, Nakatsukasa H.
  • Journal Title: Br J Surg 97(6) Pages: 934-944
  • Peer Reviewed
• [Journal Article] Evolution of prognostic factors in hepatocellular carcinoma in Japan. (2010)
  • Author(s): Nouso K, Kobayashi Y, Nakamura S, Kobayashi S, Toshimori J, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Iwasaki Y, Kobashi H, Yamamoto K.
  • Journal Title: Aliment Pharmacol Ther. 31(3) Pages: 407-414
  • Peer Reviewed
• [Journal Article] Nonalcoholic steatohepatitis-associated hepatocellular carcinoma : our case series and literature review. (2010)
  • Author(s): Takuma Y, Nouso K.
  • Journal Title: World J Gastroenterol. 16(12) Pages: 1436-1441
  • NAID: 120005053308
  • Peer Reviewed
• [Journal Article] Preoperative estimation of remnant hepatic function using fusion images obtained by (99m)Tc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography. (2010)
  • Author(s): Yumoto Y
  • Journal Title: Br J Surg Volume: 97 Pages: 934-944
  • Peer Reviewed
• [Journal Article] Time-dependent analysis of predisposing factors for the recurrence of hepatocellular carcinoma. (2010)
  • Author(s): Iwadou S
  • Journal Title: Liver International Volume: 30 Pages: 1027-1032
  • Peer Reviewed
• [Journal Article] Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease. (2010)
  • Author(s): Shoji B
  • Journal Title: J Gastroenterol Volume: 45 Pages: 1172-1182
  • Peer Reviewed
• [Journal Article] Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma. (2010)
  • Author(s): Onishi H
  • Journal Title: Hepatology International Volume: 4 Pages: 562-568
  • Peer Reviewed
• [Journal Article] Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma. (2010)
  • Author(s): Hagihara H
  • Journal Title: Int J Clin Oncol. Volume: 9-Dec
  • Peer Reviewed
• [Journal Article] Twist expression promotes migration and invasion in hepatocellular carcinoma. (2009)
  • Author(s): Matsuo N, Shiraha H, Fujikawa T, Takaoka N, Ueda N, Tanaka S, Nishina S, Nakanishi Y, Uemura M, Takaki A, Nakamura S, Kobayashi Y, Nouso K, Yagi T, Yamamoto K.
  • Journal Title: BMC Cancer 18(9) Pages: 240-240
  • NAID: 120005053307
  • Peer Reviewed
• [Presentation] B非C型肝細胞癌のハイリスクグループの設定およびその妥当性 (2010)
  • Author(s): 能祖一裕
  • Organizer: JDDW
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-15
• [Presentation] 非B非C型肝細胞癌のハイリスクグループの設定およびその妥当性 (2010)
  • Author(s): 能祖一裕
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] 高齢者肝細胞癌の治療成績 (2010)
  • Author(s): 能祖一裕
  • Organizer: 第13回高齢消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-10
• [Presentation] 非B非C型肝細胞癌の現状及び対策 (2010)
  • Author(s): 能祖一裕
  • Organizer: 第46回日本肝癌研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-08
• [Presentation] 非B非C型肝細胞癌の現状及び対策 (2010)
  • Author(s): 能祖一裕
  • Organizer: 第46回日本肝癌研究会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-07-08
• [Presentation] New glycan-markers for the diagnosis of pancreas cancer (2010)
  • Author(s): 能祖一裕
  • Organizer: Cancer congress in Singapore
  • Place of Presentation: シンガポール
  • Year and Date: 2010-06-23
• [Presentation] New glycan-markers for the diagnosis of pancreas cancer (2010)
  • Author(s): 能祖一裕
  • Organizer: Cancer Congress in Singapore
  • Place of Presentation: Singapore EXPO,シンガポール
  • Year and Date: 2010-06-23
• [Presentation] AFP20ng/ml以下の肝細胞癌におけるL3分画測定の意義 (2010)
  • Author(s): 能祖一裕
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形市
  • Year and Date: 2010-05-27
• [Presentation] 非B非C肝細胞癌のリスク集団の囲い込み (2009)
  • Author(s): 能祖一裕
  • Organizer: 第38回日本肝臓学会西部会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-12-04
• [Presentation] Recent changes of the prognostic factors of hepatocellular carcinoma. (2009)
  • Author(s): 能祖一裕
  • Organizer: 3rd IKLS with ILCA scientific session
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-04