Effect of bone formation ability using the biomimetic bone graft material with some cytocines

• Project/Area Number: 21890159
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MATSUURA Ayumu Hiroshima University, 病院, 歯科診療医 (10555155)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 歯科補綴学一般 / 骨再生 / 生体材料

Research Abstract

In order to acquire higher bone formation ability, we fabricated carbonate apatite collagen sponges with cytokines, The aim of this study is to evaluate values of these bone graft materials from points of view of the biometerial and in vitro. They had 3-dementional structures and didn't change by addition of cytokines. In carbonate apatite collagen sponges with cytokines, number of cells significantly increased compared with controls.

Research Products

• [Journal Article] Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxyapatite. A beagle dog study (2010)
  • Author(s): Kubo T, Doi K, Hayashi K, Morita K, Matsuura A, Teixeira RE, Akagawa Y.
  • Journal Title: Journal of Prosthodontic Reserch 55 Pages: 104-109
  • Peer Reviewed
• [Journal Article] Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents. (2009)
  • Author(s): Matsuura, A., Kubo, T., Doi, K., Hayashi, K., Morita, K., Yokota, R., Hayashi, H., Hirata, I., Okazaki, M., Akagawa, Y.
  • Journal Title: Dental Materlals Journal 28 Pages: 234-242
  • NAID: 10025915330
  • Peer Reviewed
• [Presentation] Development of new bone graft material using carbonate apatite-chitosan composit (2010)
  • Author(s): Maretaningtias D.A., Matsuura A., Hirata I., Doi K., Hayashi K., Morita K., Kubo T, Okazaki M, Akagawa Y.
  • Organizer: The32nd Annuol Meeting of the Japanese Society for Biomaterials
  • Place of Presentation: 広島市
  • Year and Date: 2010-11-29
• [Presentation] Cell proliferative ability of newly developed carbonate apatite-collagen sponges with some cytokines (2010)
  • Author(s): Matsuura A., Hirata I., Morita K., Doi K., Hayashi K., Koretake K., Kubo T., Okazaki M., Akagawa Y.
  • Organizer: 6th Meeting of Asian Academy of Osseointegration
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2010-11-13
• [Presentation] Fabrication and cell compatibility evaluation of newly developed carbonate apatite-chitosan scaffold for bone tissue engineering (2010)
  • Author(s): Maretaningtias D.A., Matsuura A., Hirata I., Doi K., Hayashi K., Morita K., Kubo T., Okazaki M., Akagawa Y.
  • Organizer: 6th Meeting of Asian Academy of Osseointegration
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2010-11-13
• [Presentation] New development of interconnected porous calcium hydroxyapatite/implant complex (2010)
  • Author(s): Oue H., Doi K., Koretake K., Hayashi K., Matsuura A., Morita K., Okazaki Y., Kubo T., Akagawa Y.
  • Organizer: 6th Meeting of Asian Academy of Osseointegration
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2010-11-13
• [Presentation] Cell proliferative ability of newly developed carbonate apatite-collagen sponges with some cytokines (2010)
  • Author(s): 松浦歩
  • Organizer: 6th Asian Academy of Osseointegration
  • Place of Presentation: Seoul(Korea)
  • Year and Date: 2010-11-13
• [Presentation] A fabrication of newly developed carbonate apatite-chitosan composite as a bone substitute (2010)
  • Author(s): Maretaningtias D.A., Matsuura A., Hirata I., Doi K., Kubo T., Okazaki M., Akagawa Y.
  • Organizer: Summer Seminar of the Japanese Society for Dental Materials and Devices
  • Place of Presentation: 松山市
  • Year and Date: 2010-08-29
• [Presentation] 新規サイトカイン添加型炭酸アパタイト・コラーゲン人工骨の細胞増殖能 (2010)
  • Author(s): 松浦歩, Maretaningtias Dwi Ariani, 平田伊佐雄, 土井一矢, 林和彦, 是竹克紀, 久保隆靖, 岡崎正之, 赤川安正
  • Organizer: 第55回日本歯科理工学会学術講演
  • Place of Presentation: 東京
  • Year and Date: 2010-04-18
• [Presentation] 新規サイトカイン添加型炭酸アパタイト・コラーゲン人工骨の細胞増殖能 (2010)
  • Author(s): 松浦歩
  • Organizer: 第55回日本歯科理工学会学術講演会
  • Place of Presentation: 東京都江戸川区
  • Year and Date: 2010-04-18
• [Presentation] Bone formation ability of a newly developed carbonate apatite collagen sponge scaffold (2009)
  • Author(s): Matsuura A., Kubo T., Koretake K., Doi K., Hayashi K., Morita K., Hirata I., Okazaki M., Akagawa Y.
  • Organizer: 5th Asian Academy of Osseointegration
  • Place of Presentation: バリ(インドネシア)
  • Year and Date: 2009-11-21
• [Presentation] Bone formation ability of a newly developed carbonate apatite collagen sponge scaffold (2009)
  • Author(s): 松浦歩
  • Organizer: 5th Asian Academy of Osseointegration
  • Place of Presentation: Bali
  • Year and Date: 2009-11-21
• [Presentation] 新規バイオミメティック骨移植材の骨形成能 (2009)
  • Author(s): 松浦歩, 久保隆靖, 土井一矢, 平田伊佐雄, 岡崎正之, 赤川安正
  • Organizer: 第54回日本歯科理工学会学術講演
  • Place of Presentation: 鹿児島市
  • Year and Date: 2009-10-02
• [Presentation] 新規バイオミメティック骨移植材の骨形成能 (2009)
  • Author(s): 松浦歩
  • Organizer: 第54回日本歯科理工学会学術講演会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2009-10-02