Effect of combined application of bFGF and inorganic polyphosphate-adsorbed hydroxyapatite for initial bone regeneration

• Project/Area Number: 21890160
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: MORITA Koji Hiroshima University, 病院, 歯科診療医 (30555149)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 再生医療 / 歯学 / 生体材料

Research Abstract

This study indicated that co-application of bFGF and poly (P) may provide enhanced bone formation by modulating cell proliferation and the mineralization process. It is anticipated that a combined application of bFGF and poly (P) can provide a novel method for bone regeneration in clinical use.

Research Products

• [Journal Article] Comparative evaluation of bone regeneration using spherical and irregularly shaped granules of interconnected porous hydroxyapatite. A beagle dog study (2011)
  • Author(s): Kubo T
  • Journal Title: J Prosthodont Res 55(2) Pages: 104-109
  • Peer Reviewed
• [Journal Article] Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite (2010)
  • Author(s): Morita K
  • Journal Title: Acta Biomater 6(7) Pages: 2808-2815
  • Peer Reviewed
• [Presentation] 連通多孔性ハイドロキシアパタイト・インプラント複合体の新規開発の試み (2011)
  • Author(s): 大上博史
  • Organizer: 第32回日本バイオマテリアル学会大会
  • Place of Presentation: 広島市
  • Year and Date: 2011-11-29
• [Presentation] Development of new bone graft material using carbonate apatite-chitosan composit (2010)
  • Author(s): Maretaningtias Dwi Ariani
  • Organizer: The 32^<nd> Annuol Meeting of the Japanese Society fot Biomaterials
  • Place of Presentation: Hiroshima City
  • Year and Date: 2010-11-29
• [Presentation] Fabrication and cell compatibility evaluation of newly developed carbonate apatite-chitosan scaffold for bone tissue engineering (2010)
  • Author(s): Maretaningtias Dwi Ariani
  • Organizer: 6^<th> Meeting of Asian Academy of Osseointegration
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-11-13
• [Presentation] New development of interconnected porous calcium hydroxyapatite/implant complex (2010)
  • Author(s): 大上博史
  • Organizer: 6^<th> Meeting of Asian Academy of Osseointegration
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-11-13
• [Presentation] Cell proliferative ability of newly developed carbonate apatite-collagen sponges with some cytokines (2010)
  • Author(s): Ayumu Matsuura
  • Organizer: 6^<th> Meeting of Asian Academy of Osseointegration
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-11-13
• [Presentation] 実験的に露出させたインプラント周囲のGBRに対するポリリン酸吸着人工骨の効果 (2010)
  • Author(s): 竹下亮
  • Organizer: 第40回日本口腔インプラント学会学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-09-18
• [Presentation] Application of bFGF-gelatin hydrogel complex for bone regeneration around fenestrated implants (2009)
  • Author(s): Morita K
  • Organizer: 5^<th> Asian Academy of Osseointegration
  • Place of Presentation: Bali Indonesia
  • Year and Date: 2009-11-21
• [Presentation] Bone formation ability of a newly developed carbonate apatite collagen sponge scaffold (2009)
  • Author(s): Ayumu Matsuura
  • Organizer: 5^<th> Asian Academy of Osseointegration
  • Place of Presentation: Bali Indonesia
  • Year and Date: 2009-11-21
• [Remarks] ホームページ等