Clarification in regulatory expression mechanism of lubrication functional protein SZP and therapeutic development of temporomandibular joint

• Project/Area Number: 21890163
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: KAMIYA Takashi Hiroshima University, 医薬学総合研究科, 特任助教 (40551057)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,691,000 (Direct Cost: ¥2,070,000、Indirect Cost: ¥621,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
• Keywords: SZP / サイトカイン / 機械的負荷 / 摩擦係数 / リン脂質 / 潤滑機能 / ヒアルロン酸

Research Abstract

It was suggested that SZP is regulated by growth factor and cytokine. Overloading may cause the reduction of the SZP expression and increase the frictional coefficient as the result of mechanical stress-induced cytokines. From these results, it was suggested SZP is involved in the first stage of cartilage degradation.

Research Products

• [Journal Article] Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage. (2011)
  • Author(s): Kotaro Tanimoto, Takashi Kamiya, Yuki Tanne, Ryo Kunimatsu, Motoko Yoshioka, Tomomi Mitsuyoshi, Kazuo Tanne.
  • Journal Title: Cell tissue Res. In press.
  • Peer Reviewed
• [Journal Article] Superficial zone protein affects boundary lubrication on the surface of mandibular condylar cartilage (2011)
  • Author(s): Takashi Kamiya
  • Journal Title: Cell tissue Res Volume: (In press)
  • Peer Reviewed
• [Journal Article] Effect of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes. (2010)
  • Author(s): Kamiya T, Tanimoto K, Tanne Y, Lin YY, Kunimatsu R, Yoshioka M, Tanaka N, Tanaka E, Tanne K.
  • Journal Title: J.Biomed Mater Res A. 92 Pages: 801-805
  • Peer Reviewed
• [Journal Article] 不正咬合患者群における顎関節病態と顎顔面形態の関連性 (2010)
  • Author(s): 佐野良太, 谷本幸太郎, 丹根由起, 神谷貴志, 光吉智美, 大谷淳二, 杉山拓紀, 小澤奏, 丹根一夫
  • Journal Title: 顎関節学会 31 Pages: 21-25
  • NAID: 10026256504
  • Peer Reviewed
• [Journal Article] Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes (2010)
  • Author(s): Takashi Kamiya
  • Journal Title: J Biomed Mater Res A 92(2) Pages: 801-805
  • Peer Reviewed
• [Presentation] 過度な機械的刺激による下顎頭軟骨の変性破壊機序 (2010)
  • Author(s): 神谷貴志
  • Organizer: 日本顎関節学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-07-25
• [Presentation] CD44受容体を介したヒアルロン酸によるPRG4の発現調節 (2010)
  • Author(s): 光吉智美, 神谷貴志, 谷本幸太郎, 丹根由起, 丹根一夫
  • Organizer: 第23回一般社団法人 日本顎関節学会総会・学術大会
  • Place of Presentation: 東京
• [Presentation] 過度な機械的刺激による下顎頭軟骨の変性、破壊機序 (2010)
  • Author(s): 神谷貴志, 谷本幸太郎, 丹根由起,岩渕泰憲, 光吉智美, 丹根一夫
  • Organizer: 第23回一般社団法人 日本顎関節学会総会・学術大会
  • Place of Presentation: 東京
• [Presentation] Modulation of PRG4 expression by hyaluronan through CD44 receptor. (2010)
  • Author(s): 谷本幸太郎, 神谷貴志, 谷本幸太郎, 丹根由起, Kunimatsu R, Yoshioka M, Yu-Ching H, 丹根一夫
  • Organizer: The88th International Association for Dental Research
  • Place of Presentation: Spain, Barcelona
• [Presentation] 不正咬合患者群における顎関節病態と顎顔面形態の関連性 (2010)
  • Author(s): 佐野良太, 谷本幸太郎, 丹根由起, 神谷貴志, 光吉智美, 杉山拓紀, 小澤奏, 丹根一夫
  • Organizer: 第20回日本顎変形症学会総会
  • Place of Presentation: 札幌
• [Presentation] Superficial zone protein 発現に対するヒアルロン酸の影響 (2009)
  • Author(s): 神谷貴志
  • Organizer: 日本顎関節学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2009-07-25
• [Presentation] Superficial zone protein発現に対するヒアルロン酸の影響 (2009)
  • Author(s): 光吉智美, 神谷貴志, 谷本幸太郎, 丹根由起, 丹根一夫
  • Organizer: 第22回一般社団法人 日本顎関節学会総会・学術大会
  • Place of Presentation: 東京
• [Remarks] ホームページ等