Applications of amelogenin to the induction of bone regeneration by using mesenchymal stem cells
| Project/Area Number |
21890164
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
TANNE Yuki Hiroshima University, 医歯薬学総合研究科, 助教 (50526241)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,496,000 (Direct Cost: ¥1,920,000、Indirect Cost: ¥576,000)
Fiscal Year 2010: ¥1,144,000 (Direct Cost: ¥880,000、Indirect Cost: ¥264,000)
Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000)
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| Keywords | アメロゲニン / 未分化間葉系幹細胞 / 骨再生治療 / エナメル蛋白 |
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| Research Abstract |
It is demonstrated that amelogenin increases the proliferation of MSCs by an interaction with LAMP1 through MAPK-ERK signaling pathway. In addition, amelogenin up-regulated the expressions of bone specific marker and mineralization activity in the osteogenic differentiation of MSCs. Amelogenin increases the expression of BMP-6, known as a promoting factor for bone differentiation.
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Report
(3 results)
Research Products
(9 results)
