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Development of the molecular target therapy for oral squamous cell carcinoma by tumor angiogenesis inhibit.

Research Project

Project/Area Number 21890168
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionYamaguchi University

Principal Investigator

ITASHIKI Yasutaka  Yamaguchi University, 医学部附属病院, 医員研究 (70530236)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
KeywordsBevacizumab / S-1 / 血管新生阻害 / アポトーシス / ヒト口腔細胞株 / 5-FU / ベバシズマブ / TS-1 / VEGF / 腫瘍新生血管 / Ki67 / ヒト口腔癌細胞株 / ベバチズマブ / VEGFR1 / VEGFR2
Research Abstract

Because the combination of bevacizumab and S-1 which was a 5-FU-based anticancer agent which was the molecular target drug of the vascularization repressor showed a significant antitumor effect in the implanted nude mouse of the oral squamous cell carcinoma cell, HSC-2, it was suggested that it was with new Tumor dormancy therapy for oral cancer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Presentation (5 results) Remarks (1 results)

  • [Presentation] 口腔扁平上皮癌に対するベバシズマブと5-フルオロウラシル併用効果の検討2011

    • Organizer
      第29回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      熊本市 崇城大学
    • Year and Date
      2011-01-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 口腔扁平上皮癌に対するベバシズマブと5-フルオロウラシル併用効果の検討2011

    • Author(s)
      板敷康隆
    • Organizer
      第29回 日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      熊本市 崇城大学市民ホール
    • Year and Date
      2011-01-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分子標的治療薬ベバシズマブとTS-1併用による単癌ヌードマウスに対する抗腫瘍効果2010

    • Organizer
      第55回(社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉・幕張 幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 分子標的治療薬ベバシズマブとTS-1併用による単癌ヌードマウスに対する抗腫瘍効果2010

    • Author(s)
      板敷康隆
    • Organizer
      第55回(社)日本口腔外科学会総会・学術大会.
    • Place of Presentation
      千葉・幕張 幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管新生阻害剤ベバシズマブの口腔扁平上皮癌に対する抗腫瘍効果の検討2010

    • Organizer
      第34回 日本頭頸部癌学会
    • Place of Presentation
      東京・新宿 京王プラザホテル
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Remarks] ホームページ等 なし

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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