The effect of hypothermia on the inner and outer hair cell damages due to cochlear ischemia.

• Project/Area Number: 21890173
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: HAKUBA Nobuhiro Ehime University, 医学部附属病院, 講師 (70304623)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,587,000 (Direct Cost: ¥1,990,000、Indirect Cost: ¥597,000); Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 虚血性内耳障害 / 内・外有毛細胞 / 低体温 / 突発性難聴 / 内耳虚血障害 / スナネズミ / 低体温治療 / 有毛細胞 / ABR / グルタミン酸 / 神経毒性 / 内耳虚血 / 有毛細胞障害 / 低体温療法 / 一過性内耳虚血障害 / 脱落細胞率 / 椎骨動脈

Research Abstract

The effect of post-ischemic hypothermia on the inner ear had not been clarified. We investigated whether hypothermia after transient ischemia could prevent the inner and outer hair cell damages and its therapeutic time window. The protective effect was greater when the hypothermia was induced earlier and had a longer duration.

Research Products

• [Journal Article] Ear-pick injury as a traumatic ossicular damage in Japan. (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Eur Arch Oto-Rhino-L 267(7) Pages: 1035-1039
  • Peer Reviewed
• [Journal Article] Ear-pick injury as a traumatic ossicular damage in Japan. (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Eur Arch Oto-Rhino-L 267(7) Pages: 1035-1039
  • Peer Reviewed
• [Journal Article] Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss. (2010)
  • Author(s): Hato N, Hyodo J, Takeda S, Takagi D, Okada M, Hakuba N, Gyo K.
  • Journal Title: Auris Nasus Larynx. Volume: 37 Pages: 626-630
  • Peer Reviewed
• [Journal Article] Delayed neuronal cell death in brainstem after transient brainstem ischemia in gerbils. (2010)
  • Author(s): Cao F, Hata R, Zhu P, Takeda S, Yosbida T, Hakuba N, Sakanaka M, Gyo K
  • Journal Title: BMC Neurosci. Volume: 14 Pages: 115-115
  • Peer Reviewed
• [Journal Article] Ear-pick injury as a traumatic ossicular damage in Japan (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Eur Arch Oto-Rhino -L (In press)
  • Peer Reviewed
• [Journal Article] Basic Fibroblast Growth Factor Combined with Atelocollagen for Closing Chronic Tympanic Membrane Perforations in 87 Patients (2010)
  • Author(s): Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T
  • Journal Title: Otol Neurotol. 31 Pages: 118-121
  • Peer Reviewed
• [Journal Article] Prednisolone prevents transient ischemia-induced cochlear damage in gerbils. (2009)
  • Author(s): Maetani T, Hyodo J, Takeda S, Hakuba N, Kiyofumi G.
  • Journal Title: Acta Otolaryngol Suppl. 562 Pages: 24-27
  • Peer Reviewed
• [Journal Article] Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils. (2009)
  • Author(s): Watanabe F, Hakuba N, Gyo K
  • Journal Title: Neurosci Lett. 267 Pages: 135-138
  • Peer Reviewed
• [Journal Article] Ischemic tolerance in the cochlea. (2009)
  • Author(s): Takeda S, Hata R, Cao F, Yoshida T, Hakuba N, Hato N, Gyo K.
  • Journal Title: Neurosci Lett. 262 Pages: 263-266
  • Peer Reviewed
• [Journal Article] Glutamate agonist causes irreversible degeneration of inner hair cells. (2009)
  • Author(s): Hyodo J, Hakuba N, Hato N, Takeda Shoichirou, Okada, Omotehara, Gyo K.
  • Journal Title: Neuroreport. 23 Pages: 1255-1259
  • Peer Reviewed
• [Journal Article] Glutamate agonist causes irreversible degeneration of inner hair cells (2009)
  • Author(s): Hyodo J, Hakuba N, Hato N, Takeda Shoichirou, Okada, Omotehara, Gyo K.
  • Journal Title: Neuroreport 23 Pages: 1255-1259
  • Peer Reviewed
• [Journal Article] Ischemic tolerance in the cochlea (2009)
  • Author(s): Takeda S, Hata R, Cao F, Yoshida T, Hakuba N, Hato N, Gyo K.
  • Journal Title: Neurosci Lett. 262 Pages: 263-266
  • Peer Reviewed
• [Journal Article] Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils (2009)
  • Author(s): Watanabe F, Hakuba N, Gyo K.
  • Journal Title: Neurosci Lett. 267 Pages: 135-138
  • Peer Reviewed
• [Journal Article] Prednisolone prevents transient ischemia-induced cochlear damage in gerbils (2009)
  • Author(s): Maetani T, Hyodo J, Takeda S, Hakuba N, Kiyofumi G.
  • Journal Title: Acta Otolaryngol Suppl. 562 Pages: 24-27
  • Peer Reviewed
• [Presentation] Glutamate agonist causes irreversible degeneration of inner hair cells (2010)
  • Author(s): Hakuba N, Gyo K
  • Organizer: Inner Ear Biology(一般講演)
  • Place of Presentation: チェコ
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 喜多八幡浜耳鼻咽喉科医会講演会(教育講演)
  • Place of Presentation: 愛媛
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 岡山Translation研究会(特別講演)
  • Place of Presentation: 岡山
• [Presentation] 穿孔性中耳炎に対する鼓膜再生治療 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 東予耳鼻科会(特別講演)
  • Place of Presentation: 愛媛
• [Presentation] 鼓膜再生による新しい穿孔性中耳の治療法 (2010)
  • Author(s): 白馬伸洋
  • Organizer: 信州耳鼻咽喉科臨床問題懇話会(招待講演)
  • Place of Presentation: 長野
• [Presentation] Glutamate agonist causes irreversible degeneration of inner hair cells (2010)
  • Author(s): Hakuba N
  • Organizer: Inner Ear Biology
  • Place of Presentation: チェコ共和国
• [Presentation] 耳鼻咽喉科の再生治療 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 愛媛県医師会生涯研究(特別講演)
  • Place of Presentation: 愛媛
• [Presentation] MRSA中耳炎に対する治療 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 栃木下野耳鼻咽喉科アレルギー感染症研究会(招待講演)
  • Place of Presentation: 栃木
• [Presentation] 虚血性内耳病変の発症機序と臨床 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 東大阪ORL研究会(特別講演)
  • Place of Presentation: 大阪
• [Presentation] 新しい鼓膜穿孔閉鎖法 (2009)
  • Author(s): 白馬伸洋
  • Organizer: 第5回明石耳鼻咽喉科学術講演会(特別講演)
  • Place of Presentation: 兵庫
• [Book] アテロコラーゲン/シリコン膜とヒト線維芽細胞増殖因子(bFGF)製剤を用いた鼓膜穿孔閉鎖術(遺伝子医学MOOK再生遺伝子治療 患者までとどいている再生誘導治療,第1版)(田畑康彦編) (2009)
  • Author(s): 白馬伸洋
  • Publisher: 大阪:メディカルドゥ
• [Remarks] ホームページ等