Study of pathogenic mechanism of respiratory inflammation and investigation of involvement of epigenetic regulation
| Project/Area Number |
21890174
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|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
EITOKU Masamitsu Kochi University, 教育研究部・医療学系, 助教 (50552733)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,626,000 (Direct Cost: ¥2,020,000、Indirect Cost: ¥606,000)
Fiscal Year 2010: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2009: ¥1,378,000 (Direct Cost: ¥1,060,000、Indirect Cost: ¥318,000)
|
|---|
| Keywords | インジウム化合物 / 産業医学 / エピジェネティクス / 酸化ストレス / 呼吸器炎症 |
|---|
| Research Abstract |
I performed intratracheal instillation of indium oxide (In_2O_3) using acatalasemic mice which lack the activity of catalase. Comparison of acatalasemic and wild-type mice showed significant difference in body weight change, increasing of relative lung weight and damage of lung tissue after 9 weeks, twice in a week instillation.
In the field of the indium-compound toxicity study, these results showed the involvement of oxidative stress to lung damage caused by exposure to indium compounds and gave us novel cue for future research.
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Report
(3 results)
Research Products
(15 results)
