| Budget Amount *help |
¥2,626,000 (Direct Cost: ¥2,020,000、Indirect Cost: ¥606,000)
Fiscal Year 2010: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2009: ¥1,378,000 (Direct Cost: ¥1,060,000、Indirect Cost: ¥318,000)
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| Research Abstract |
I performed intratracheal instillation of indium oxide (In_2O_3) using acatalasemic mice which lack the activity of catalase. Comparison of acatalasemic and wild-type mice showed significant difference in body weight change, increasing of relative lung weight and damage of lung tissue after 9 weeks, twice in a week instillation.
In the field of the indium-compound toxicity study, these results showed the involvement of oxidative stress to lung damage caused by exposure to indium compounds and gave us novel cue for future research.
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