Development of the novel magnetic resonance imaging technique for the early detection and quantitative assessment of denaturalization of articular cartilage

• Project/Area Number: 21890178
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: TAKAYAMA Yukihisa Kyushu University, 大学病院, 医員 (60546563)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,106,000 (Direct Cost: ¥1,620,000、Indirect Cost: ¥486,000); Fiscal Year 2010: ¥741,000 (Direct Cost: ¥570,000、Indirect Cost: ¥171,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 磁気共鳴画像 / T1ρ計算画像 / 変形性膝関節症 / 関節軟骨 / 定量的評価 / 形態評価 / T1rho mapping / プロテオグリカン / T1ρ強調画像 / プロテオグ

Research Abstract

T1ρ mapping is a useful diagnostic tool to evaluate noninvasively and quantitatively the denaturalization of articular cartilage caused by osteoarthritis. It enables not only depicting an early stage of the denatured articular cartilage but also assessing the severity grades of the denaturalization.

Research Products

• [Journal Article] A simplified method of T(1)ρ mapping in clinical assessment of knee joint. (2010)
  • Author(s): Yukihisa Takayama, Masamitsu Hatakenaka, Takashi Yoshiura, Ken Okazaki, Kei Nishikawa, Okuaki Tomoyuki, Zimine Ivan, Hiroshi Honda
  • Journal Title: Magn Reson Med Sci. 9(4) Pages: 209-215
  • Peer Reviewed
• [Journal Article] A Simplified Method of T1ρ Relaxation Mapping : Clinical Utility for a Quantitative Assessment of Joint Cartilage (2010)
  • Author(s): Yukihisa Takayama, et al.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 9-4 Pages: 209-215
  • Peer Reviewed
• [Presentation] T1ρ計算画像を用いたヒト膝関節軟骨の定量的評価:肉眼的な関節軟骨変性の評価との対比 (2010)
  • Author(s): 高山幸久
  • Organizer: 第37回日本磁気共鳴医学会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2010-10-01
• [Presentation] MRIを用いた膝関節軟骨の定量的評価-T1ρ mapを利用した関節軟骨障害の推測- (2010)
  • Author(s): 高山幸久
  • Organizer: 第70回九州MR研究会
  • Place of Presentation: アクロス福岡国際会議場(福岡県福岡市)
  • Year and Date: 2010-05-24
• [Presentation] MRIを用いた膝関節軟骨の定量的評価-T1ρmapを利用した関節軟骨障害の推測- (2010)
  • Author(s): 高山幸久
  • Organizer: 第70回MR研究会 教育講演
  • Place of Presentation: 福岡市
  • Year and Date: 2010-05-14
• [Presentation] T1ρ計算画像を用いたヒト膝関節軟骨の定量的評価:手術標本との対比 (2010)
  • Author(s): 高山幸久、畠中正光、吉浦敬、津嶋秀俊、岡崎賢、岩本幸英、西川啓、小原真、本田浩
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば市
• [Presentation] T1ρ強調計算画像を用いたヒト膝関節軟骨の定量的評価 (2009)
  • Author(s): 高山幸久
  • Organizer: 第37回 日本磁気共鳴医学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Comparison of Different Quantitative Approaches in T1ρ Relaxation Time Assessment of the Knee (2009)
  • Author(s): 高山幸久
  • Organizer: 第17回 国際磁気共鳴医学会
  • Place of Presentation: アメリカ合衆国・ホノルル
  • Year and Date: 2009-04-22
• [Presentation] Comparison of Different Quantitative Approaches in T1ρ Relaxation Time Assessment of the Knee. (2009)
  • Author(s): Yukihisa Takayama, Masamitsu Hatakenaka, Takashi Yoshiura, Ken Okazaki, Kei Nishikawa, Okuaki Tomoyuki, Zimine Ivan, Hiroshi Honda
  • Organizer: 17th annual meeting of the International Society for Magnetic resonance in Medicine
  • Place of Presentation: Honolulu, Hawaii, USA
• [Presentation] T1ρ計算画像を用いたヒト膝関節軟骨の定量的評価 (2009)
  • Author(s): 高山幸久、畠中正光、吉浦敬、岡崎賢、井澤敏明、岩本幸英、西川啓、奥秋智幸、Ivan Zimine、本田浩
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜市
• [Remarks] ホームページ等