Development of molecular imaging probes applied for multimodality

Research Project

Project/Area Number	21890179
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Kyushu University
Principal Investigator	SANO Kohei Kyushu University, 薬学研究科, 特定助教 (00546476)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,431,000 (Direct Cost: ¥1,870,000、Indirect Cost: ¥561,000) Fiscal Year 2010: ¥1,066,000 (Direct Cost: ¥820,000、Indirect Cost: ¥246,000) Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywords	放射線 / 分子認識 / 薬学
Research Abstract	We established a radiolabeled γ-polyglutamic acid (γ-PGA) complex as a nanocarrier for molecular imaging with high cell uptake and low toxicity. This ^<111> In labeled PGA complex with strong anionic surface showed low cytotoxicity, indicating the high biocompatiblility. ^<111> In-PGA complex exhibited the high uptake by macrophage. Moreover, ^<111> In-PGA complex clearly visualized the sentinel lymph node (SLN) with single photon emission computed tomography (SPECT), suggesting that ^<111> In-PGA complex is useful as a SLN imaging probe with low cytotoxicity.

Report

(3 results)