Development of molecular imaging probes applied for multimodality

• Project/Area Number: 21890179
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: SANO Kohei Kyushu University, 薬学研究科, 特定助教 (00546476)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,431,000 (Direct Cost: ¥1,870,000、Indirect Cost: ¥561,000); Fiscal Year 2010: ¥1,066,000 (Direct Cost: ¥820,000、Indirect Cost: ¥246,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 放射線 / 分子認識 / 薬学

Research Abstract

We established a radiolabeled γ-polyglutamic acid (γ-PGA) complex as a nanocarrier for molecular imaging with high cell uptake and low toxicity. This ^<111> In labeled PGA complex with strong anionic surface showed low cytotoxicity, indicating the high biocompatiblility. ^<111> In-PGA complex exhibited the high uptake by macrophage. Moreover, ^<111> In-PGA complex clearly visualized the sentinel lymph node (SLN) with single photon emission computed tomography (SPECT), suggesting that ^<111> In-PGA complex is useful as a SLN imaging probe with low cytotoxicity.

Research Products

• [Patent(Industrial Property Rights)] 抗原または薬物送達複合体 (2011)
  • Inventor(s): 佐々木均、黒崎友亮、北原隆志、藤秀人、由井克之、平山謙二、森田公一、向高弘、間賀田泰寛、小川美香子、佐野紘平
  • Industrial Property Rights Holder: 国立大学法人 長崎大学
  • Filing Date: 2011-02-24
• [Patent(Industrial Property Rights)] 抗原または薬物送達複合体 (2011)
  • Inventor(s): 佐々木均, 黒崎友亮, 北原隆志, 藤秀人, 由井克之, 平山謙二, 森田公一, 向高弘, 間賀田泰寛, 小川美香子, 佐野紘平
  • Industrial Property Rights Holder: 国立大学法人 長崎大学
  • Filing Date: 2011-02-24
  • Overseas