The relationship between chromosomal instability and spindle assembly checkpoint in gastric cancers

• Project/Area Number: 21890181
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: MIMA Kosuke Kyushu University, 医学部附属病院, 医員 (00546559)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 癌 / 細胞周期 / 遺伝子 / マイクロアレイ / 紡錘体チェックポイント / Mad2 / Cdc20 / DNA ploidy / BubRl

Research Abstract

Gastric cancers show high frequency of DNA aneuploidy, a phenotype of chromosomal instability. It is suggested that the abnormal spindle assembly checkpoint is involved in DNA aneuploidy, but the underlying mechanism is still unclear. We studied the mechanism by assessing the expression of Cdc20 in gastric cancer. The mRNA expression of Cdc20 was not associated with DNA aneuploidy in vitro and gastric cancer patients.

Research Products

• [Journal Article] TS-1+CDDP療法により治癒切除が可能となった局所進行十二指腸癌の1例 (2011)
  • Author(s): 美馬浩介、掛地吉弘、佐伯浩司、吉田倫太郎、吉永敬士、森田勝、武冨紹信、調憲、前原喜彦
  • Journal Title: 日本消化器外科学会雑誌 in press
  • NAID: 130004560723
  • Peer Reviewed
• [Journal Article] Liver functional volumetry for portal vein embolization using a newly developed (99m) Tc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system. (2011)
  • Author(s): Beppu T, Hayashi H, Okabe H, Masuda T, Mima K, Otao R, et al.
  • Journal Title: J Gastroenterol
  • NAID: 10029313401
  • Peer Reviewed
• [Journal Article] The role of thermal ablation for colorectal liver metastases in the era of effective chemotherapy. (2011)
  • Author(s): Mima K, Beppu T, Masuda T, Otao R, Miyake K, Okabe H, et al
  • Journal Title: Thermal Med 27(1) Pages: 1-8
  • NAID: 10028165487
  • Peer Reviewed
• [Journal Article] Conversion therapyを念頭においた切除不能大腸癌肝転移に対する分子標的治療 (2011)
  • Author(s): 美馬浩介、別府透、林尚子、増田稔郎、宮本裕士、近本亮、石河隆敏、渡邊雅之、高森啓史、馬場秀夫
  • Journal Title: 外科 73 Pages: 257-261
• [Journal Article] 大腸癌肝転移に対する新しい治療戦略 (2011)
  • Author(s): 美馬浩介
  • Journal Title: 癌と化学療法 Volume: 37 Pages: 2075-2079
• [Journal Article] Conversion therapyを念頭においた切除不能大腸癌肝転移に対する分子標的治療 (2011)
  • Author(s): 美馬浩介
  • Journal Title: 外科 Volume: 73 Pages: 257-261
• [Journal Article] The role of Thermal Ablation for Colorectal Liver Metastases in the Era of Effective Chemotherapy (2011)
  • Author(s): Kosuke Mima, et al.
  • Journal Title: Thermal Medicine Volume: 27 Pages: 1-8
  • NAID: 10028165487
  • Peer Reviewed
• [Journal Article] TS-1+CDDP療法により治癒切除が可能となった局所進行十二指腸癌の1例 (2011)
  • Author(s): 美馬浩介
  • Journal Title: 日本消化器外科学会雑誌 Volume: (in press)
  • NAID: 130004560723
  • Peer Reviewed
• [Journal Article] Laparoscopy-assisted resection through the mini medianlaparotomy for undiagnosed liver tumor with ascending colon cancer : Report of a Case (2011)
  • Author(s): Kosuke Mima, et al.
  • Journal Title: Surgery Today Volume: (in press)
  • Peer Reviewed
• [Journal Article] A pimary neuroendocrine tumor in the liver treated by hepatectomy : Report of a case (2011)
  • Author(s): Kosuke Mima, et al.
  • Journal Title: Surgery Today Volume: (in press)
  • Peer Reviewed
• [Journal Article] Small solid pseudopapillary tumor of the pancreas in a 32-year-old man : report of a case. (2010)
  • Author(s): Mima K, Hirota M, Abe S, Iwatsuki M, Imamura H, Tsuruzoe S, et al.
  • Journal Title: Surg Today 40 Pages: 772-6
  • NAID: 10027397128
  • Peer Reviewed
• [Journal Article] Currrent Organ Topics : 大腸癌II.大腸癌肝転移に対する新しい治療戦略 (2010)
  • Author(s): 美馬浩介、別府透、林尚子、増田稔郎、近本亮、石河隆敏、渡邊雅之、高森啓史、馬場秀夫
  • Journal Title: 癌と化学療法 37 Pages: 2075-2079
• [Journal Article] Small Solid Pseudopapillary Tumor of the Pancreas in a 32-Year-Old Man : Report of a Case (2010)
  • Author(s): Kosuke Mima, et al.
  • Journal Title: Surgery Today Volume: 40 Pages: 772-776
  • NAID: 10027397128
  • Peer Reviewed
• [Journal Article] Submucosal tumour in a young girl. (2009)
  • Author(s): Hayashi N, Mima K, Nagai Y, Baba Y, Imamura Y, Hiyoshi Y, et al.
  • Journal Title: Gut 58 Pages: 1040-1040
  • Peer Reviewed
• [Journal Article] Laparoscopy-assisted resection through the mini medianlaparotomy for undiagnosed liver tumor with ascending colon cancer : Report of a Case.
  • Author(s): Mima K, Beppu T, Chikamoto A, Ishiko T, Horino K, Hayashi N, et al.
  • Journal Title: Surg Today in press
  • Peer Reviewed
• [Journal Article] A primary neuroendocrine tumor in the liver treated by hepatectomy : Report of a case.
  • Author(s): Mima K, Beppu T, Murata A, Otao R, Okabe H, Masuda T, et al.
  • Journal Title: Surg Today in press
  • NAID: 10030229919
  • Peer Reviewed
• [Presentation] 新規薬剤:ミリプラチン・リピオドールの肝細胞癌に対する肝動脈化学塞栓療法における可能性 (2010)
  • Author(s): 美馬浩介、別府透、岡部和利、杉山眞一、増田稔郎、太田尾龍、岡部弘尚、近本亮、堀野敬、石河隆敏、高森啓史、池田理、山下康行、馬場秀夫、
  • Organizer: 第48回癌治療学会学術集会パネルディスカッション
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2010-10-29
• [Presentation] 新規薬剤:ミリプラチン・リピオドールの肝細胞癌に対する肝動脈化学塞栓療法における可能性 (2010)
  • Author(s): 美馬浩介
  • Organizer: 第48回癌治療学会学術集会
  • Place of Presentation: グランドプリンスホテル京都
  • Year and Date: 2010-10-29
• [Presentation] Advances in Thermal Ablation for Colorectal Liver Metastases (2010)
  • Author(s): Mima K, Beppu T, Ishiko T, Chikmoto A, Masuda T, Okabe K,, et al.
  • Organizer: The 5^<th> Asian Congress of Hyperthermic Oncology
  • Place of Presentation: 福岡(九州大学医学部百年講堂)
  • Year and Date: 2010-09-11
• [Presentation] Advances in Thermal Ablation for Colorectal Liver Metastases (2010)
  • Author(s): 美馬浩介
  • Organizer: アジアハイパーサーミア腫瘍学会第5回大会
  • Place of Presentation: 九州大学医学部百年講堂
  • Year and Date: 2010-09-11
• [Presentation] Recent advances in the management of hepatocellular carcinoma and the current role of local ablative therapies (2010)
  • Author(s): Mima K, Beppu T, Ishiko T, Chikamoto A, Masuda T, Okabe H, et al.
  • Organizer: The 9^<th> international Conference of The Asian Clinical Oncology Society
  • Place of Presentation: 岐阜(岐阜グランドホテル)
  • Year and Date: 2010-07-26
• [Presentation] Recent advances in the management of hegatocellular carcinoma and the current role of local ablative therapies (2010)
  • Author(s): Kosuke Mima
  • Organizer: 9^<th> international Conference of The Aaian Clinical Oncology Society
  • Place of Presentation: 岐阜グランドホテル
  • Year and Date: 2010-06-26