The relationship between chromosomal instability and spindle assembly checkpoint in gastric cancers
| Project/Area Number |
21890181
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MIMA Kosuke Kyushu University, 医学部附属病院, 医員 (00546559)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | 癌 / 細胞周期 / 遺伝子 / マイクロアレイ / 紡錘体チェックポイント / Mad2 / Cdc20 / DNA ploidy / BubRl |
|---|
| Research Abstract |
Gastric cancers show high frequency of DNA aneuploidy, a phenotype of chromosomal instability. It is suggested that the abnormal spindle assembly checkpoint is involved in DNA aneuploidy, but the underlying mechanism is still unclear. We studied the mechanism by assessing the expression of Cdc20 in gastric cancer. The mRNA expression of Cdc20 was not associated with DNA aneuploidy in vitro and gastric cancer patients.
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Report
(3 results)
Research Products
(22 results)
