Elucidation of inhibition mechanism of ameloblastoma growth・ differentiation by Sprouty regulating MAPK cascade.

• Project/Area Number: 21890185
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu University
• Principal Investigator: TAKETOMI Takaharu Kyushu University, 大学院・歯学研究院, 助教 (10553290)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: MAPK / Sprouty / EGF / FGF 刺激 / エナメル上皮腫 / MAPK経路 / Sprouty2 / FGFシグナル / EGFシグナル

Research Abstract

expression were enhanced by EGF stimulation. Spry2 induced by Ras-ERK signal cascade was negative regulator for ERK activation by FGF signaling, but accelerated it by EGF signaling in AM-1 cells. Spry2 might be associated with the growth of ameloblastoma through the promotion of EGF signaling.

Research Products

• [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling. (2011)
  • Author(s): Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S.
  • Journal Title: Biochem Biophys Res Commun. Volume 404, Issue 4 Pages: 1076-1082
• [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling (2011)
  • Author(s): Matsumura K, et at.
  • Journal Title: Biochem Biophys Res Commun. Volume: 404 Pages: 1076-1082
  • Peer Reviewed
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): K.Matsumura, T.Taketomi, K.Yoshizaki, D.Yoshiga, T.Maehara, S.Arai, T.Sanui, A.Yoshimura, S.Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling. (2010)
  • Author(s): D.Yoshiga, T.Taketomi, D.Muratsu, T.Onimura, H.Shiraishi, T.Sanada, T.Kobayashi, S.Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration. (2010)
  • Author(s): T.Sanui, T.Fukuda, T.Taketomi, T.Hamachi, K.Maeda.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling. (2010)
  • Author(s): D.Yoshiga, et al.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-16
• [Presentation] YB-1 is important for amelogenin induced periodontal regeneration. (2010)
  • Author(s): T.Fukuda, et al.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-16
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): K.Matsumura, et al.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-16
• [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation. (2010)
  • Author(s): Takaharu Taketomi, Daigo yoshiga, Kaori matsumura, Takeshi Mitsuyasu, Terukazu Sanui, Takao Fukuda, Akihiko Yoshimura, Seiji Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-15
• [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation. (2010)
  • Author(s): Takaharu Taketomi, et al.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-15
• [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration. (2010)
  • Author(s): T.Sanui, et al.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Place of Presentation: Spain
  • Year and Date: 2010-07-15
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): Kaori Matsumura, Takaharu taketomi, Masaaki Sasaguri, Takeshi Mitsuyasu, Tomomi Tsujiguchi, Shinsaku Arai, Daigo Yoshiga, Terukazu Sanui, Akihiko Yoshimura, Seiji Nakamura.
  • Organizer: The 6th Congress of International Cleft Palate Foundation in Conjunction with 14th national Congress of Korean Cleft Lip and Palate Association
  • Year and Date: 2010-06-10
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): Matsumura K, et al.
  • Organizer: The 6th Congress of International Cleft Palate Foundation in Conjunction with 14th national Congress of Korean Cleft Lip and Palate Association
  • Place of Presentation: Korea
  • Year and Date: 2010-06-10
• [Presentation] Analysis of the molecular mechanisms of periodontal regeneration by EMD. (2010)
  • Author(s): Takao Fukuda, Terukazu Sanui, Takaharu Taketomi, Takafumi Hamachi, Katsumasa Maeda.
  • Organizer: The 5th International Symposum on Dental and Craniofacial Morphogenesis and Tissue Regeneration : A View from Stem Cell Research
  • Year and Date: 2010-02-05
• [Presentation] Analysis of the novel protein bound to amelogenin in periodontal tissue cells (2009)
  • Author(s): 福田隆男
  • Organizer: The 11^<th> KSCD-JSCD joint meeting
  • Place of Presentation: Jeju, Korea
• [Presentation] 歯周組織細胞群における新規アメロジェニン結合タンパク質の検索 (2009)
  • Author(s): 福田隆男
  • Organizer: 第52回日本歯周病学会春期学術大会
  • Place of Presentation: 岡山、日本
• [Remarks] ホームページ等
• [Remarks]
  • URL: http://hyoka.ofc.kyushu-u.ac.jp/search/index.html