Functional roles of phosphatidylinositol signaling in relationship between adiponectin and periodontal disease.

• Project/Area Number: 21890188
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Nihon University (2010); Kyushu University (2009)
• Principal Investigator: KAMIO Noriak Nihon University, 歯学部, ポスト・ドクトラル・フェロー (60546472)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: アディポネクチン / ジアシルグリセロールキナーゼ / アポトーシス

Research Abstract

The present study investigated whether diacylglycerol kinases (DGKs), enzymes functioning in sub-cellular signaling pathways, had a role on adiponectin-induced apoptosis and IL-6 secretion. This study suggested that the adiponectin-induced apoptosis and secretion of IL-6 involves DGKs.

Research Products

• [Journal Article] Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species. (2011)
  • Author(s): Kamio N, Akifusa S, Yamashita Y
  • Journal Title: Free Radic Res. 45 Pages: 336-341
  • Peer Reviewed
• [Journal Article] Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species. (2011)
  • Author(s): Kamio N, et al.
  • Journal Title: Free Radic Res. Volume: 45 Pages: 336-341
  • Peer Reviewed
• [Journal Article] Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells. (2010)
  • Author(s): Akifusa S, Kamio N, Shimazaki Y, Yamaguchi N, Nonaka K, Yamashita Y
  • Journal Title: J Cell Biochem. 111 Pages: 597-606
  • Peer Reviewed
• [Journal Article] Expression levels of adiponectin receptors and periodontitis. (2010)
  • Author(s): Yamaguchi N, Hamachi T, Kamio N, Akifusa S, Masuda K, Nakamura Y, Nonaka K, Maeda K, Hanazawa S, Yamashita Y
  • Journal Title: J Periodontal Res. 45 Pages: 96-300
  • Peer Reviewed
• [Journal Article] Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species. (2010)
  • Author(s): Fujimoto A, Akifusa S, Kamio N, Hirofuji T, Nonaka K, Yamashita Y
  • Journal Title: Free Radic Res. 44 Pages: 128-134
  • Peer Reviewed
• [Journal Article] Expression levels of adiponectin receptors and periodontitis. (2010)
  • Author(s): Yamaguchi N, et al.
  • Journal Title: J Periodontal Res. Volume: 45 Pages: 296-300
  • Peer Reviewed
• [Journal Article] Involvement of the JAK-STAT pathway and SOCS3 in the regulation of adiponectin-generated reactive oxygen species in murine macrophage RAW 264 cells. (2010)
  • Author(s): Akifusa S, et al.
  • Journal Title: J Cell Biochem. Volume: 111 Pages: 597-606
  • Peer Reviewed
• [Journal Article] Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species (2010)
  • Author(s): Fujimoto A, et al.
  • Journal Title: Free Radic Res. 44 Pages: 128-134
  • Peer Reviewed
• [Journal Article] Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomycetemcomitans. (2009)
  • Author(s): Kamio N, Akifusa S, Yamaguchi N, Nonaka K, Yamashita Y
  • Journal Title: FEMS Immunol Med Microbiol. 56 Pages: 241-247
  • Peer Reviewed
• [Journal Article] Anti-inflammatory activity of a globular adiponectin function on RAW 264 cells stimulated by lipopolysaccharide from Aggregatibacter actinomyicetemcomitans (2009)
  • Author(s): Kamio N, et al.
  • Journal Title: FEMS Immunol Med Microbiol 56 Pages: 241-247
  • Peer Reviewed
• [Presentation] アディポネクチンはジアシルグリセロールキナーゼを介してアポトーシスを誘導する (2009)
  • Author(s): 神尾宜昌,秋房住郎,山口登,野中和明,山下喜久
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ、新潟県
• [Presentation] アディポネクチンはジアシルグリセロールキナーゼを介してアポトーシスを誘導する (2009)
  • Author(s): 神尾宜昌
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟市
• [Presentation] 球状アディポネクチンが誘導するマクロファージのアポトーシスにおける活性酸素種の関与について (2009)
  • Author(s): 秋房住郎
  • Organizer: 第58回日本口腔衛生学会・総会
  • Place of Presentation: 岐阜市