Establishment of mouse model of carcinomatous peritonitis for tailor maid cancer therapy.

Research Project

Project/Area Number	21890191
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Nagasaki University
Principal Investigator	KANETAKA Kengo Nagasaki University, 病院, 助教 (10549570)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥2,301,000 (Direct Cost: ¥1,770,000、Indirect Cost: ¥531,000) Fiscal Year 2010: ¥1,092,000 (Direct Cost: ¥840,000、Indirect Cost: ¥252,000) Fiscal Year 2009: ¥1,209,000 (Direct Cost: ¥930,000、Indirect Cost: ¥279,000)
Keywords	胃癌 / 癌性腹膜炎 / 動物モデル
Research Abstract	Cancer stem cell marker CD44 expression in T3/4 gastric cancer. We investigated the correlation between expression of CD44 and clinicopathological factors such as carcinomatous peritonitis in patients with advanced T3/4 gastric adenocarcinoma. Present study did not show any correlation between the expression of CD44, known cancer stem cell marker, and clinicopathological factors. However, even among patients with advanced (T3-4) gastric adenocarcinoma, CD44 positive group showed poorer prognosis than CD44 negative one. These results suggested that CD44, putative cancer stem cell marker, might be involved in tumor progression, although the precise mechanism remains to be elucidated.

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