Elucidation of the bone formation mechanism through Akt-mTOR

• Project/Area Number: 21890194
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: ROKUTANDA Satoshi Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (60549608)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 骨格形成機構 / Akt-mTOR / Runx2 / Stat1,3 / S6K / 4EBP1 / Akt / mTOR / Stat13 / TAK / Stat pathway

Research Abstract

I clarified a function of Akt for the bone formation until now. Akt regulates a large number of signal molecules in the down stream. I decided to perform function elucidation for the frame formation mechanism of those signal molecules.

Research Products

• [Journal Article] Overexpression of CRK II increases migration and invasive potential in oral squamous cell carcinoma (2011)
  • Author(s): Shin-ichi Yamada, Souichi Yanamoto, Goro Kawasaki, Satoshi Rokutanda, Hisanobu Yonezawa Akiko Kawakita, Takayuki K Nemoto
  • Journal Title: Cancer Letters
  • NAID: 120006985180
• [Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma (2011)
  • Author(s): Shin-ichi Yamada, Souichi Yanamoto, Goro Kawasaki, Satoshi Rokutanda, Hisanobu Yonezawa Akiko Kawakita, Takayuki K Nemoto
  • Journal Title: Cancer Letters
  • NAID: 120006985180
  • Peer Reviewed
• [Journal Article] Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation (2010)
  • Author(s): Masaki Mikasa・Satoshi Rokutanda・Hisato Komori・Kosei Ito・Ying Sze Tsang・Yuki Date・Carolina A.Yoshida・Toshihisa Komori
  • Journal Title: Journal of Bone and Mineral Metabolism
  • NAID: 10029024664
• [Remarks] ホームページ等
  • URL: http://naosite.lb.nagasaki-u.ac.jp/dspace/handle/10069/24743