Potential of Induced Pluripotent Stem (iPS) Cells for the Regeneration of the Tracheal Wall

• Project/Area Number: 21890207
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: IMAIZUMI Mitsuyoshi Fukushima Medical University, 医学部, 助手 (30554422)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,574,000 (Direct Cost: ¥1,980,000、Indirect Cost: ¥594,000); Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000); Fiscal Year 2009: ¥1,352,000 (Direct Cost: ¥1,040,000、Indirect Cost: ¥312,000)
• Keywords: iPS細胞 / 軟骨分化誘導 / 気管再生 / 気道再建

Research Abstract

Our study demonstrated that iPS cells have the potency to differentiate into chondrogenic cells, as shown by the appearance of Alcian blue-stained colonies and expression of a cartilage-associated gene of collagen type II in vitro. Implanted iPS cells were confirmed to exist in the 3D scaffold in vivo. Cartilage-like tissue was regenerated in tracheal defect using iPS cells. Our results suggest the potential of iPS cells for the regeneration of the tracheal wall.

Research Products

• [Journal Article] Potential of Induced Pluripotent Stem (iPS) Cells for the Regeneration of the Tracheal Wall. (2010)
  • Author(s): Mitsuyoshi Imaizumi, Yukio Nomoto, Takashi Sugino, Masao Miyake, Ikuo Wada, Tatsuo Nakamura, Koichi Omori
  • Journal Title: Annals of Otology, Rhinology & Laryngology 119(10) Pages: 697-703
  • Peer Reviewed
• [Journal Article] Potential of Induced Pluripotent Stem (iPS) Cells for the Regeneration of the Tracheal Wall (2010)
  • Author(s): Mitsuyoshi Imaizumi
  • Journal Title: Annals of Otology, Rhinology & Laryngology Volume: 119(10) Pages: 697-703
  • Peer Reviewed
• [Presentation] iPS細胞を利用した軟骨組織再生:気管組織再生の試み (2011)
  • Author(s): 今泉光雅
  • Organizer: 第7回信越セミナー
  • Place of Presentation: 長野
  • Year and Date: 2011-03-05
• [Presentation] iPS細胞を利用した軟骨組織再生:気管組織再生の試み (2010)
  • Author(s): 今泉光雅
  • Organizer: 第62回日本気管食道科学会総会ならびに学術講演会
  • Place of Presentation: 別府
  • Year and Date: 2010-11-05
• [Presentation] Variation of safety for tracheal regeneration with iPS cells. (2010)
  • Author(s): 今泉光雅
  • Organizer: The 114^<th> Annual Meeting & OTO EXPO American Academy of Otolaryngology. Head and Neck Surgery
  • Place of Presentation: Boston
  • Year and Date: 2010-09-28
• [Presentation] Tracheal regeneration with iPS cells. (2010)
  • Author(s): 今泉光雅
  • Organizer: Phonosurgery Symposium in Kyoto
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-11
• [Presentation] Tracheal regeneration with ipS cells (2010)
  • Author(s): Mitsuyoshi Imaizumi
  • Organizer: Phonosurgery Symposium in Kyoto
  • Place of Presentation: 京都
  • Year and Date: 2010-09-11
• [Presentation] 気管欠損部におけるiPS細胞を利用した軟骨組織再生の試み (2010)
  • Author(s): 今泉光雅
  • Organizer: 第59回日本耳鼻咽喉科学会・東北地方部会連合学術講演会
  • Place of Presentation: 秋田
  • Year and Date: 2010-07-24
• [Presentation] 気管欠損部におけるiPS細胞を利用した組織再生の可能性 (2010)
  • Author(s): 今泉光雅
  • Organizer: 第111回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-20
• [Presentation] 気管欠損部におけるiPS細胞を利用した組織再生の可能性 (2010)
  • Author(s): 今泉光雅
  • Organizer: 第111回 日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-20
• [Presentation] Potential of IPS Cells for the Regeneration of the Tracheal Wall (2010)
  • Author(s): 今泉光雅
  • Organizer: The 90th Annual Meeting of the American Broncho-Esophagological Association
  • Place of Presentation: Las Vegas
  • Year and Date: 2010-04-28
• [Presentation] IPS細胞移植における奇形腫形成:気管と腹部への移植において (2010)
  • Author(s): 今泉光雅
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 気管欠損へのiPS細胞含有人工材料移植の試み (2010)
  • Author(s): 今泉光雅
  • Organizer: 第22回日本喉頭科学会
  • Place of Presentation: 下関
  • Year and Date: 2010-03-05
• [Remarks] ホームページ等
  • URL: http://ameblo.jp/regenerative-kyoto/entry-10708008469.html
• [Remarks]
  • URL: http://www.ips-tokku.cira.kyoto-u.ac.jp/thesis/archives/201011/19-094057.html
• [Remarks]
  • URL: http://www.ips-network.mext.go.jp/open/2010/10/potential_of_induced_pluripotent_stem_cells_for_the_regeneration_of_the_tracheal_wall.html
• [Remarks]
  • URL: http://www.minpo.jp/view.php?pageId=4107&blockId=9794853&newsMode=article
• [Remarks]
  • URL: http://ameblo.jp/regenerative-kyoto/entry-10708008469.html
• [Remarks]
  • URL: http://www.ips-tokku.cira.kyoto-u.ac.jp/thesis/archives/201011/19-094057.html
• [Remarks]
  • URL: http://www.ips-network.mext.go.jp/open/2010/10/potential_of_induced_pluripotent_stem_cells_for_the_regeneration_of_the_tracheal_wall.html
• [Remarks]
  • URL: http://www.minpo.jp/view.php?pageId=4107&blockId=9794853&newsMode=article