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Pathophysiological Role of Angiotensin Receptor Binding Protein in Salt-sensitive Hypertension

Research Project

Project/Area Number 21890212
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionYokohama City University

Principal Investigator

MITSUHASHI Hiroshi  Yokohama City University, 医学部, 助教 (90517020)

Co-Investigator(Renkei-kenkyūsha) TAMURA Kouichi  横浜市立大学, 医学部, 准教授 (40285143)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥988,000 (Direct Cost: ¥760,000、Indirect Cost: ¥228,000)
Fiscal Year 2009: ¥1,092,000 (Direct Cost: ¥840,000、Indirect Cost: ¥252,000)
Keywords高血圧学 / 受容体 / 腎障害 / 生体分子 / 高血圧 / トランスレーショナルリサーチ
Research Abstract

Dahl salt-sensitive hypertensive rats (DS rats, 3 wks of age) were divided into three groups for oral administration of vehicle (vehicle group) or ARB either continuously from 6 to 16 wks of age (continuous ARB group) or transiently from 3 to 10 wks of age (transient ARB group) and fed high salt diet from 6 to 16 wks of age. DS rats fed a normal salt diet were used as controls (control group). Not only continuous ARB treatment (SBP 149±9 mmHg) but also transient ARB treatment (SBP 142±7 mmHg) significantly improved hypertension at 16 wks of age with reduction of urinary protein excretion, as compared to vehicle group (SBP 199±15 mmHg). With respect to the regulation of ATRAP expression in the kidney, the renal ATRAP expression was significantly suppressed in vehicle group compared with control group. However, transient ARB treatment as well as continuous ARB treatment significantly recovered the suppressed renal ATRAP expression. These results indicate that the transiently administrated ARB-mediated sustained activation of renal ATRAP expression may play a role in the long-term therapeutic effects of ARB even after withdrawal on hypertension and renal injury in salt-induced hypertension.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Expression of angiotensin II type 1 receptor interacting molecule in normal human kidney and IgA nephropathy.2010

    • Author(s)
      Masuda S, Mitsuhashi H(他18名), Umemura S, et al.
    • Journal Title

      Am J Physiol Renal Physiol. 299

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sustained inhibition of oxidized low-density lipoprotein is involved in the long-term therapeutic effects of apheresis in dialysis patients.2010

    • Author(s)
      Tsurumi-Ikeya Y, Mitsuhashi H(他12名), Umemura S, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 30

      Pages: 1058-1065

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy.2010

    • Author(s)
      Masuda S, Mitsuhashi H, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.2009

    • Author(s)
      Mitsuhashi H, Tamura K(他18名), Umemura S, et al.
    • Journal Title

      Atherosclerosis 207

      Pages: 186-190

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis2009

    • Author(s)
      Shigenaga A, Tamura K, Mitsuhashi H, et al.
    • Journal Title

      Nephron Clin Pract. 112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎硬化症. CKD患者における診断・評価の要点2009

    • Author(s)
      田村功一, 東公一, 三橋洋
    • Journal Title

      腎と透析 67

      Pages: 213-234

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis2009

    • Author(s)
      三橋洋, 田村功一, et al.
    • Journal Title

      Atherosclerosis 207

      Pages: 186-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of Losartan on Ambulatory Short-Term Blood Pressure Variability and Cardiovascular Remodeling in Hypertensive Patients on Hemodialysis2009

    • Author(s)
      Mitsuhashi H, et al.
    • Organizer
      Renal Week 2009. 42nd Annual Meeting & Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      San Diego, CA(米国)
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of Losartan on Ambulatory Short-Term Blood Pressure Variability and Cardiovascular Remodeling in Hypertensive Patients on Hemodialysis. Renal Week 2009.2009

    • Author(s)
      Mitsuhashi H, et al.
    • Organizer
      42nd Annual Meeting & Scientific Exposition of American Society of Nephrology
    • Place of Presentation
      San Diego, CA
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.yokohama-cu.ac.jp/amedrc/res/tamura_1005.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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