| Project/Area Number |
21890231
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
TSUJI Toshiaki Wakayama Medical University, 医学部, 学内助教 (20549737)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,458,000 (Direct Cost: ¥2,660,000、Indirect Cost: ¥798,000)
Fiscal Year 2010: ¥1,521,000 (Direct Cost: ¥1,170,000、Indirect Cost: ¥351,000)
Fiscal Year 2009: ¥1,937,000 (Direct Cost: ¥1,490,000、Indirect Cost: ¥447,000)
|
|---|
| Keywords | 癌 / 腫瘍融解性ウイルス / 発現制御 / 種瘍融解性ウイルス |
|---|
| Research Abstract |
Therapies for unresectable advanced and recurrent gastric cancer have been unsatisfactory. New therapies using oncolytic viruses have been expected. These viruses have mutations on their genes and only replicate in tumor cells, but these mutated genes sometimes spoil their oncolytic ability. To enhance their oncolysis, various attempts have been done. In this study, we selected appropriate gene for individual gastric cancer and construct virus expressing that gene to enhance oncolysis. Immunohistochemical study revealed gene expression of individual gastric cancer and therapeutic experiments were undergone and enhanced therapeutic effects were observed.
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