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The role of EDHF-mediated responses under pathological conditions

Research Project

Project/Area Number 21890233
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKyushu Dental College

Principal Investigator

GOTO Kenichi  Kyushu Dental College, 歯学部, 助教 (30549887)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,197,000 (Direct Cost: ¥1,690,000、Indirect Cost: ¥507,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥962,000 (Direct Cost: ¥740,000、Indirect Cost: ¥222,000)
Keywords内皮機能 / 内皮由来過分極因子 / 一酸化窒素 / 食塩感受性高血圧
Research Abstract

High salt diet up-regulates EDHF-mediated relaxation through the activation of BKCa in mesenteric arteries of Dahl salt-sensitive hypertensive rats. Up-regulation of EDHF compensates for the loss of NO to maintain overall endothelial function in salt-sensitive hypertension.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Enalapril treatment alters the contribution of EETs but not gap junctions to EDHF activity in mesenteric arteries of spontaneously hypertensive rats.2009

    • Author(s)
      Ellis A, Goto K, Chaston DJ, Brackenbury TD, Meaney KR, Falck JR, Wojcikiewicz RJH, Hill CE.
    • Journal Title

      J Pharmacol Exs Ther 330

      Pages: 413-422

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cilostamide produces hyperpolarization associated with KATP channel activation, but does not augment EDHF-mediated hyperpolarization in the rat mesenteric arteries.2009

    • Author(s)
      Kansui Y, Goto K, Fujii K, Oniki H, Matsumura K, Iida M.
    • Journal Title

      Clin Exp Pharm Physiol 36

      Pages: 729-733

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Dahl食塩感受性高血圧ラットの腸間膜動脈ではBKCaチャンネルの活性化により内皮由来過分極因子を介した弛緩反応が保持されており、障害されたNOの代償機構として内皮機能保護的に作用している2010

    • Author(s)
      後藤健一、松村潔、大坪俊夫、寒水康雄、鬼木秀幸
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Effects of Na-K-2Cl Cotranspoter NKCC1 on Endothelial Function in Arteries of Salt Sensitive Hypertensive Rats.2010

    • Author(s)
      後藤健一, 松村潔, 大坪俊夫, 飯田三雄
    • Organizer
      The 23^<rd> scientific meeting of the international society of hypertension
    • Place of Presentation
      Vancouver Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Na-K-2Cl Cotranspoter NKCC1 on Endothelial Function in Arteries of Salt Sensitive Hypertensive Rats2010

    • Author(s)
      Goto K, Matsumura K, Ohtsubo T, Iida M
    • Organizer
      The 23^<rd> scientific meeting of the international society of hypertension
    • Place of Presentation
      Vancouver Canada
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dah1食塩感受性ラットの摘出腸間膜動脈では、Na^+/K^+/2Cl^- cotransporter阻害薬による内皮依存性弛緩反応の改善は認められない2009

    • Author(s)
      後藤健一、松村潔、大坪俊夫、飯田三雄
    • Organizer
      第32回日本高血圧学会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dahl食塩感受性ラットの摘出腸間膜動脈では、Na+/K+/2Cl- cotransporter阻害薬による内皮依存性弛緩反応の改善は認められない2009

    • Author(s)
      後藤健一、松村潔、大坪俊夫、飯田三雄
    • Organizer
      第32回日本高血圧学会総会
    • Place of Presentation
      大津
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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