The role of EDHF-mediated responses under pathological conditions

• Project/Area Number: 21890233
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyushu Dental College
• Principal Investigator: GOTO Kenichi Kyushu Dental College, 歯学部, 助教 (30549887)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,197,000 (Direct Cost: ¥1,690,000、Indirect Cost: ¥507,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥962,000 (Direct Cost: ¥740,000、Indirect Cost: ¥222,000)
• Keywords: 内皮機能 / 内皮由来過分極因子 / 一酸化窒素 / 食塩感受性高血圧

Research Abstract

High salt diet up-regulates EDHF-mediated relaxation through the activation of BKCa in mesenteric arteries of Dahl salt-sensitive hypertensive rats. Up-regulation of EDHF compensates for the loss of NO to maintain overall endothelial function in salt-sensitive hypertension.

Research Products

• [Journal Article] Enalapril treatment alters the contribution of EETs but not gap junctions to EDHF activity in mesenteric arteries of spontaneously hypertensive rats. (2009)
  • Author(s): Ellis A, Goto K, Chaston DJ, Brackenbury TD, Meaney KR, Falck JR, Wojcikiewicz RJH, Hill CE.
  • Journal Title: J Pharmacol Exs Ther 330 Pages: 413-422
  • Peer Reviewed
• [Journal Article] Cilostamide produces hyperpolarization associated with KATP channel activation, but does not augment EDHF-mediated hyperpolarization in the rat mesenteric arteries. (2009)
  • Author(s): Kansui Y, Goto K, Fujii K, Oniki H, Matsumura K, Iida M.
  • Journal Title: Clin Exp Pharm Physiol 36 Pages: 729-733
  • Peer Reviewed
• [Presentation] Dahl食塩感受性高血圧ラットの腸間膜動脈ではBKCaチャンネルの活性化により内皮由来過分極因子を介した弛緩反応が保持されており、障害されたNOの代償機構として内皮機能保護的に作用している (2010)
  • Author(s): 後藤健一、松村潔、大坪俊夫、寒水康雄、鬼木秀幸
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
• [Presentation] Effects of Na-K-2Cl Cotranspoter NKCC1 on Endothelial Function in Arteries of Salt Sensitive Hypertensive Rats. (2010)
  • Author(s): 後藤健一, 松村潔, 大坪俊夫, 飯田三雄
  • Organizer: The 23^<rd> scientific meeting of the international society of hypertension
  • Place of Presentation: Vancouver Canada
• [Presentation] Effects of Na-K-2Cl Cotranspoter NKCC1 on Endothelial Function in Arteries of Salt Sensitive Hypertensive Rats (2010)
  • Author(s): Goto K, Matsumura K, Ohtsubo T, Iida M
  • Organizer: The 23^<rd> scientific meeting of the international society of hypertension
  • Place of Presentation: Vancouver Canada
• [Presentation] Dah1食塩感受性ラットの摘出腸間膜動脈では、Na^+/K^+/2Cl^- cotransporter阻害薬による内皮依存性弛緩反応の改善は認められない (2009)
  • Author(s): 後藤健一、松村潔、大坪俊夫、飯田三雄
  • Organizer: 第32回日本高血圧学会
  • Place of Presentation: 大津
  • Year and Date: 2009-10-02
• [Presentation] Dahl食塩感受性ラットの摘出腸間膜動脈では、Na+/K+/2Cl- cotransporter阻害薬による内皮依存性弛緩反応の改善は認められない (2009)
  • Author(s): 後藤健一、松村潔、大坪俊夫、飯田三雄
  • Organizer: 第32回日本高血圧学会総会
  • Place of Presentation: 大津