Analysis of statin-induced autophagy and cell death in cell-type-specific manner
| Project/Area Number |
21890238
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
ARAKI Makoto Iwate Medical University, 薬学部, 助教 (20552904)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
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| Keywords | 薬学 / 蛋白質 |
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| Research Abstract |
Purpose of this study is to address a molecular mechanism of side effects of statins that are used for hypercholesterolemia. It is well known that statins induce rhabdomyolysis in a low frequency in patients. During this research period, we found that cell-death of rhabdomyosarcoma A204 cells is induced by statins. We also identified a potential gene that affects the cell-death caused by statins. This gene has an essential role for cell cycle progression. We are now currently examining how gene functions in the process of statin-induced cell death of A204 cells.
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Report
(3 results)
Research Products
(9 results)
