Analysis of statin-induced autophagy and cell death in cell-type-specific manner

• Project/Area Number: 21890238
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Iwate Medical University
• Principal Investigator: ARAKI Makoto Iwate Medical University, 薬学部, 助教 (20552904)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000); Fiscal Year 2009: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
• Keywords: 薬学 / 蛋白質

Research Abstract

Purpose of this study is to address a molecular mechanism of side effects of statins that are used for hypercholesterolemia. It is well known that statins induce rhabdomyolysis in a low frequency in patients. During this research period, we found that cell-death of rhabdomyosarcoma A204 cells is induced by statins. We also identified a potential gene that affects the cell-death caused by statins. This gene has an essential role for cell cycle progression. We are now currently examining how gene functions in the process of statin-induced cell death of A204 cells.

Research Products

• [Journal Article] エネルギー代謝調節鍵酵素PDK4の正常時および病態時の発現制御におけるPGC-1の意義 (2009)
  • Author(s): 荒木信、本島清人
  • Journal Title: 内分泌・糖尿病科 第29巻、2号
• [Presentation] スタチン誘導性の細胞死に対する耐性細胞の解析 (2010)
  • Author(s): 荒木信
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] スタチンによる細胞種特異的な細胞障害因子の探索 (2009)
  • Author(s): 荒木信
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-23
• [Presentation] スタチンによる細胞種特異的な細胞障害因子の探索 (2009)
  • Author(s): 荒木信
  • Organizer: 第82回 日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2009-10-23
• [Presentation] 高コレステロール血症治療薬スタチンによるオートファジー誘導に関する解析 (2009)
  • Author(s): 荒木信
  • Organizer: 日本薬学会東北支部第8回生物化学若手研究者セミナー
  • Place of Presentation: 東北薬科大学(招待講演)
  • Year and Date: 2009-09-12
• [Presentation] 高コレステロール血症治療薬スタチンによるオートファジー誘導に関する解析 (2009)
  • Author(s): 荒木信
  • Organizer: 日本薬学会東北支部第8回 生物化学若手研究者セミナー
  • Place of Presentation: 東北薬科大学
  • Year and Date: 2009-09-12
• [Presentation] Role of isoprenoid metabolism in autophagy induced by statins (2009)
  • Author(s): 荒木信
  • Organizer: JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
  • Place of Presentation: 岩手医科大学(国際学会)
  • Year and Date: 2009-07-24
• [Presentation] Role of isoprenoid metabolism in autophagy induced by statins (2009)
  • Author(s): 荒木信
  • Organizer: JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
  • Place of Presentation: 岩手医科大学矢巾キャンパス
  • Year and Date: 2009-07-24
• [Remarks] ホームページ等