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Analysis of statin-induced autophagy and cell death in cell-type-specific manner

Research Project

Project/Area Number 21890238
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionIwate Medical University

Principal Investigator

ARAKI Makoto  Iwate Medical University, 薬学部, 助教 (20552904)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Keywords薬学 / 蛋白質
Research Abstract

Purpose of this study is to address a molecular mechanism of side effects of statins that are used for hypercholesterolemia. It is well known that statins induce rhabdomyolysis in a low frequency in patients. During this research period, we found that cell-death of rhabdomyosarcoma A204 cells is induced by statins. We also identified a potential gene that affects the cell-death caused by statins. This gene has an essential role for cell cycle progression. We are now currently examining how gene functions in the process of statin-induced cell death of A204 cells.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 Other

All Journal Article (1 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] エネルギー代謝調節鍵酵素PDK4の正常時および病態時の発現制御におけるPGC-1の意義2009

    • Author(s)
      荒木信、本島清人
    • Journal Title

      内分泌・糖尿病科 第29巻、2号

    • Related Report
      2010 Final Research Report
  • [Presentation] スタチン誘導性の細胞死に対する耐性細胞の解析2010

    • Author(s)
      荒木信
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] スタチンによる細胞種特異的な細胞障害因子の探索2009

    • Author(s)
      荒木信
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] スタチンによる細胞種特異的な細胞障害因子の探索2009

    • Author(s)
      荒木信
    • Organizer
      第82回 日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高コレステロール血症治療薬スタチンによるオートファジー誘導に関する解析2009

    • Author(s)
      荒木信
    • Organizer
      日本薬学会東北支部第8回生物化学若手研究者セミナー
    • Place of Presentation
      東北薬科大学(招待講演)
    • Year and Date
      2009-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 高コレステロール血症治療薬スタチンによるオートファジー誘導に関する解析2009

    • Author(s)
      荒木信
    • Organizer
      日本薬学会東北支部第8回 生物化学若手研究者セミナー
    • Place of Presentation
      東北薬科大学
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of isoprenoid metabolism in autophagy induced by statins2009

    • Author(s)
      荒木信
    • Organizer
      JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
    • Place of Presentation
      岩手医科大学(国際学会)
    • Year and Date
      2009-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of isoprenoid metabolism in autophagy induced by statins2009

    • Author(s)
      荒木信
    • Organizer
      JBS Biofrontier Symposium on Biochemistry of pH Homeostasis and Proton Circuit
    • Place of Presentation
      岩手医科大学矢巾キャンパス
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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