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The analysis of AMPK-mTOR signaling pathway

Research Project

Project/Area Number 21890244
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionKitasato University

Principal Investigator

TATSUHIRO Sato  Kitasato University, 薬学部, 助教 (70547893)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsシグナル伝達 / mTOR / AMPK / プロテオーム / Rheb / ブロテオーム解析
Research Abstract

AMPK-mTOR signaling pathway plays an important role in the regulation of cellular energy. Although dysregulation of mTOR activity is observed in many types of cancer cells, the precise mechanism remains unclear. In this research, we performed a comprehensive analysis of the proteins expressed in cultured cells and found novel proteins involved in AMPK-mTOR signaling pathway. Our studies provide a new mechanism of AMPK-mTOR signaling pathway and will contribute to the development of new anti-cancer drugs.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Presentation (4 results)

  • [Presentation] mTORシグナル伝達因子のプロテオーム解析2010

    • Author(s)
      佐藤龍洋
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Final Research Report
  • [Presentation] mTORシグナル伝達因子のプロテオーム解析2010

    • Author(s)
      佐藤龍洋
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] mTOR 活性化型変異体の同定と解析2009

    • Author(s)
      佐藤龍洋
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] mTOR活性変異体の同定およびRheb-mTORシグナル伝達の解析2009

    • Author(s)
      佐藤龍洋
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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