| Project/Area Number |
21890244
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kitasato University |
|---|
Principal Investigator |
TATSUHIRO Sato Kitasato University, 薬学部, 助教 (70547893)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | シグナル伝達 / mTOR / AMPK / プロテオーム / Rheb / ブロテオーム解析 |
|---|
| Research Abstract |
AMPK-mTOR signaling pathway plays an important role in the regulation of cellular energy. Although dysregulation of mTOR activity is observed in many types of cancer cells, the precise mechanism remains unclear. In this research, we performed a comprehensive analysis of the proteins expressed in cultured cells and found novel proteins involved in AMPK-mTOR signaling pathway. Our studies provide a new mechanism of AMPK-mTOR signaling pathway and will contribute to the development of new anti-cancer drugs.
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